Evidence map›Paper›PMID 33875606›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Temporally and spatially partitioned neuropeptide release from individual clock neurons.

Markus K Klose, Marcel P Bruchez, David L Deitcher, Edwin S Levitan

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Journal of biological rhythms · 2026
    Article
  2. Article
  3. Soma CaCurrent biology : CB · 2026
    Article
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  7. Article
  8. Article
  9. Review
  10. Article
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  12. Article
  13. Review
  14. Article
  15. Timed receptor tyrosine kinase signaling couples the central and a peripheral circadian clock inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Markus K KloseDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261.ORCID 0000-0001-5861-2366
Marcel P BruchezMolecular Biosensor and Imaging Center, Carnegie Mellon University, Pittsburgh, PA 15213.ORCID 0000-0002-7370-4848
David L DeitcherDepartment of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853.ORCID 0000-0002-8512-8868
Edwin S LevitanDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261; elevitan@pitt.edu.ORCID 0000-0003-3319-1344

Funding

Dense-Core Vesicle Circulation, Capture and Synaptic Neuropeptide ReleaseR01NS032385 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI EDWIN S LEVITAN · 1995 to 2026
$13.0M
High Throughput Approaches for Cell-Specific Synapse CharacterizationRF1MH114103 · NIMH · CARNEGIE-MELLON UNIVERSITY · PI BARTH, ALISON L, BRUCHEZ, MARCEL P · 2017 to 2018
$2.5M
A New Method for Imaging Neuropeptide Release in the BrainR21NS115023 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEVITAN, EDWIN S · 2019 to 2020
$444k
SINGLE MOLECULE DETECTION OF ION CHANNELS IN NEURONSR21MH100612 · NIMH · CARNEGIE-MELLON UNIVERSITY · PI BARTH, ALISON L, BRUCHEZ, MARCEL P · 2013 to 2014
$420k
NIMH NIH HHS R21 MH100612NIMH NIH HHS RF1 MH114103NINDS NIH HHS R01 NS032385NINDS NIH HHS R21 NS115023
6 · The paper itself

Abstract

Neuropeptides control rhythmic behaviors, but the timing and location of their release within circuits is unknown. Here, imaging in the brain shows that synaptic neuropeptide release by

Indexed as

Circadian RhythmAnimalsBrainCircadian ClocksDrosophilaIn Vitro TechniquesMaleMicroscopy, ConfocalNeuronsNeuropeptidesPresynaptic TerminalsNeuropeptidescircadianfluorogen-activating proteinneuropeptide releasepeptidergic transmissionsynapse

Identifiers

PMID33875606
PMCPMC8092580

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.