Evidence map›Paper›PMID 33875594›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Homeostatic regulation of T follicular helper and antibody response to particle antigens by IL-1Ra of medullary sinus macrophage origin.

Xinwen Lin, Trix Twelkmeyer, Danming Zhu, Li Zhang, Yang Zhao, Chao Zhang, Yoichiro Iwakura, Guangxun Meng, Zhaolin Hua, Bingyu Yan and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Xinwen LinInstitut Pasteur of Shanghai, Guangzhou Women and Children's Medical Center Joint Center for Infection and Immunity, Chinese Academy of Sciences, 200031 Shanghai, China.ORCID 0000-0001-9739-770X
Trix TwelkmeyerInstitut Pasteur of Shanghai, Guangzhou Women and Children's Medical Center Joint Center for Infection and Immunity, Chinese Academy of Sciences, 200031 Shanghai, China.
Danming ZhuThe Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, 100101 Beijing, China.
Li ZhangShandong Center for Disease Control and Prevention, 250014 Jinan, China.
Yang ZhaoThe Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, 100101 Beijing, China.
Chao ZhangThe Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, 100101 Beijing, China.ORCID 0000-0001-8126-8145
Yoichiro IwakuraDivision of Experimental Animal Immunology, Center for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science, 278-0022 Chiba, Japan.ORCID 0000-0002-9934-5775
Guangxun MengInstitut Pasteur of Shanghai, Guangzhou Women and Children's Medical Center Joint Center for Infection and Immunity, Chinese Academy of Sciences, 200031 Shanghai, China.ORCID 0000-0003-4634-4661
Zhaolin HuaThe Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, 100101 Beijing, China.
Bingyu YanShandong Center for Disease Control and Prevention, 250014 Jinan, China.
William J LiuNational Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, 102206 Beijing, China.
Zhongguang LuoDepartment of Digestive Diseases of Huashan Hospital, Fudan University, 200040 Shanghai, China.
Sitang GongThe Joint Program in Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 510623 Guangzhou, China.
Hairong ChenThe Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, 100101 Beijing, China.
Shuran LiThe Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, 100101 Beijing, China; shuran.li@beigene.com baidong_hou@sun5.ibp.ac.cn htang@ips.ac.cn.
Baidong HouThe Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, 100101 Beijing, China; shuran.li@beigene.com baidong_hou@sun5.ibp.ac.cn htang@ips.ac.cn.
Hong TangInstitut Pasteur of Shanghai, Guangzhou Women and Children's Medical Center Joint Center for Infection and Immunity, Chinese Academy of Sciences, 200031 Shanghai, China; shuran.li@beigene.com baidong_hou@sun5.ibp.ac.cn htang@ips.ac.cn.
Chinese Academy of Sciences · CNShandong Center for Disease Control and Prevention · CNFudan University · CNGuangzhou Medical University · CNNational Institute for Viral Disease Control and Prevention · CNTokyo University of Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis B virus (HBV) vaccines are composed of surface antigen HBsAg that spontaneously assembles into subviral particles. Factors that impede its humoral immunity in 5% to 10% of vaccinees remain elusive. Here, we showed that the low-level interleukin-1 receptor antagonist (IL-1Ra) can predict antibody protection both in mice and humans. Mechanistically, murine IL-1Ra-inhibited T follicular helper (Tfh) cell expansion and subsequent germinal center (GC)-dependent humoral immunity, resulting in significantly weakened protection against the HBV challenge. Compared to soluble antigens, HBsAg particle antigen displayed a unique capture/uptake and innate immune activation, including IL-1Ra expression, preferably of medullary sinus macrophages. In humans, a unique polymorphism in the RelA/p65 binding site of IL-1Ra enhancer associated IL-1Ra levels with ethnicity-dependent vaccination outcome. Therefore, the differential IL-1Ra response to particle antigens probably creates a suppressive milieu for Tfh/GC development, and neutralization of IL-1Ra would resurrect antibody response in HBV vaccine nonresponders.

Indexed as

AnimalsAntibodiesAntibodies, ViralAntibody FormationAntigensB-LymphocytesGerminal CenterHepatitis B Surface AntigensHepatitis B VaccinesHepatitis B virusHumansImmunity, HumoralImmunogenicity, VaccineInterleukin 1 Receptor Antagonist ProteinMacrophagesMiceAntibodiesAntibodies, ViralAntigensHepatitis B Surface AntigensHepatitis B VaccinesInterleukin 1 Receptor Antagonist ProteinReceptors, Interleukin-1GCIL-1Ramedullary sinus macrophageparticle antigensTfh

Identifiers

PMID33875594
PMCPMC8092388
OpenAlexW3152908363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.