Evidence map›Paper›PMID 33875586›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Heme-binding protein CYB5D1 is a radial spoke component required for coordinated ciliary beating.

Lijuan Zhao, Haibo Xie, Yunsi Kang, Yiwen Lin, Gai Liu, Miho Sakato-Antoku, Ramila S Patel-King, Bing Wang, Cuihong Wan, Stephen M King and 2 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Heme-binding protein CYB5D1 couples intraflagellar redox to calcium signaling for coordinated flagellar beating.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Comparative Proteomics of Plasma and Flagellar Membranes inInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Oncology research · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Characterization ofPlants (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Lijuan ZhaoKey Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, 430072 Wuhan, China.ORCID 0000-0002-5884-5140
Haibo XieInstitute of Evolution and Marine Biodiversity, College of Marine Life Science, Ocean University of China, 266003 Qingdao, China.
Yunsi KangInstitute of Evolution and Marine Biodiversity, College of Marine Life Science, Ocean University of China, 266003 Qingdao, China.
Yiwen LinKey Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, 430072 Wuhan, China.ORCID 0000-0002-6802-133X
Gai LiuKey Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, 430072 Wuhan, China.ORCID 0000-0002-8303-194X
Miho Sakato-AntokuDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT 06032-3305.
Ramila S Patel-KingDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT 06032-3305.
Bing WangHubei Key Lab of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, China.ORCID 0000-0003-3050-4712
Cuihong WanHubei Key Lab of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, China.ORCID 0000-0002-6028-3239
Stephen M KingDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT 06032-3305.ORCID 0000-0002-5484-5530
Chengtian ZhaoInstitute of Evolution and Marine Biodiversity, College of Marine Life Science, Ocean University of China, 266003 Qingdao, China; chengtian_zhao@ouc.edu.cn huangky@ihb.ac.cn.ORCID 0000-0003-1236-914X
Kaiyao HuangKey Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, 430072 Wuhan, China; chengtian_zhao@ouc.edu.cn huangky@ihb.ac.cn.ORCID 0000-0001-8669-1065
Chinese Academy of Sciences · CNUConn Health · USCentral China Normal University · CNOcean University of China · CNQingdao National Laboratory for Marine Science and Technology · CN

Funding

MOLECULAR ANALYSIS OF FLAGELLAR DYNEIN FUNCTIONR01GM051293 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KING, STEPHEN M · 1995 to 2020
$6.9M
NIGMS NIH HHS R01 GM051293
6 · The paper itself

Abstract

Coordinated beating is crucial for the function of multiple cilia. However, the molecular mechanism is poorly understood. Here, we characterize a conserved ciliary protein CYB5D1 with a heme-binding domain and a cordon-bleu ubiquitin-like domain. Mutation or knockdown of

Indexed as

AnimalsAxonemeChlamydomonasCiliaCytochromes b5DyneinsFlagellaHeme-Binding ProteinsMicrotubulesMutationZebrafishCytochromes b5DyneinsHeme-Binding ProteinsChlamydomonasciliamotilityredoxzebrafish

Identifiers

PMID33875586
PMCPMC8092603
OpenAlexW3156333147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.