ArticleProceedings of the National Academy of Sciences of the United States of America2021
Noninvasive high-frequency oscillations riding spikes delineates epileptogenic sources.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 70 citations in OpenAlex.
- Sleep magnetoencephalography enhances detection and source imaging of seizures and fast oscillations in focal cortical dysplasia.Epilepsia · 2026Article
- Scalp high-frequency activity differentiates neonates with seizures from healthy neonates and indicates postneonatal epilepsy risk.Epilepsia · 2026Article
- Photothrombosis-induced cortical stroke mouse model produces focal electrographic epileptic human biomarkers.Experimental neurology · 2026Article
- Mapping epileptogenic brain using a unified spatial-temporal-spectral source imaging framework.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Power-to-power cross-frequency coupling as a novel approach for temporal lobe seizure detection and analysis.Neuroscience informatics · 2025Article
- Self-supervised data-driven approach defines pathological high-frequency oscillations in epilepsy.Epilepsia · 2025Article
- Deep learning-based EEG source imaging is robust under varying electrode configurations.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- High-frequency oscillations >250 Hz in people with Down syndrome and associated Alzheimer's disease dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Modeling Emotional Arousal With Turbulence Measured by EEG.Psychophysiology · 2025Article
- Flexible Deep-Brain Probe for High-Fidelity Multi-Scale Recording of Epileptic Network Dynamics.Micromachines · 2025Article
- Deep learning in intracranial EEG for seizure detection: advances, challenges, and clinical applications.Frontiers in neuroscience · 2025Review
- Spikes on ripples are better interictal biomarkers of epilepsy than spikes or ripples.Brain communications · 2025Article
- Seizure Sources Can Be Imaged from Scalp EEG by Means of Biophysically Constrained Deep Neural Networks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Electroencephalographic source imaging of spikes with concurrent high-frequency oscillations is concordant with the clinical ground truth.Epilepsia · 2024Article
- Spike-spindle coupling during sleep and its mechanism explanation in childhood focal epilepsy.Cognitive neurodynamics · 2024Article
- Practical measurements distinguishing physiological and pathological stereoelectroencephalography channels based on high-frequency oscillations in the human brain.Epilepsia open · 2024Article
- Spike ripples localize the epileptogenic zone best: an international intracranial study.Brain : a journal of neurology · 2024Article
- Pathological and Physiological High-frequency Oscillations on Electroencephalography in Patients with Epilepsy.Neuroscience bulletin · 2024Review
- Robust compression and detection of epileptiform patterns in ECoG using a real-time spiking neural network hardware framework.Nature communications · 2024Article
- Low-density scalp electrical source imaging of the ictal onset zone network using source coherence maps.Frontiers in neurology · 2024Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
High-frequency oscillations (HFOs) are a promising biomarker for localizing epileptogenic brain and guiding successful neurosurgery. However, the utility and translation of noninvasive HFOs, although highly desirable, is impeded by the difficulty in differentiating pathological HFOs from nonepileptiform high-frequency activities and localizing the epileptic tissue using noninvasive scalp recordings, which are typically contaminated with high noise levels. Here, we show that the consistent concurrence of HFOs with epileptiform spikes (pHFOs) provides a tractable means to identify pathological HFOs automatically, and this in turn demarks an epileptiform spike subgroup with higher epileptic relevance than the other spikes in a cohort of 25 temporal epilepsy patients (including a total of 2,967 interictal spikes and 1,477 HFO events). We found significant morphological distinctions of HFOs and spikes in the presence/absence of this concurrent status. We also demonstrated that the proposed pHFO source imaging enhanced localization of epileptogenic tissue by 162% (∼5.36 mm) for concordance with surgical resection and by 186% (∼12.48 mm) with seizure-onset zone determined by invasive studies, compared to conventional spike imaging, and demonstrated superior congruence with the surgical outcomes. Strikingly, the performance of spike imaging was selectively boosted by the presence of spikes with pHFOs, especially in patients with multitype spikes. Our findings suggest that concurrent HFOs and spikes reciprocally discriminate pathological activities, providing a translational tool for noninvasive presurgical diagnosis and postsurgical evaluation in vulnerable patients.
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