Evidence map›Paper›PMID 33875547›Full record

ArticleJournal of bacteriology2021

Mutations in Ehrlichia chaffeensis Genes ECH_0660 and ECH_0665 Cause Transcriptional Changes in Response to Zinc or Iron Limitation.

Ascención Torres-Escobar, María D Juárez-Rodríguez, Roman R Ganta

Open access · hybridAbstract read
In one paragraph

Article in Journal of bacteriology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ascención Torres-Escobar *Center of Excellence for Vector-Borne Diseases, Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA.
María D Juárez-Rodríguez *Center of Excellence for Vector-Borne Diseases, Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA.
Roman R GantaCenter of Excellence for Vector-Borne Diseases, Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA.
Kansas State University · US

Funding

Vector and Host Contributions to the Regulation of E. Chaffeensis Gene ExpressionR01AI070908 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI ROMAN R. GANTA · 2008 to 2026
$6.9M
Vaccines Against Ehrlichia and Anaplasma Species InfectionsR01AI152418 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI GANTA, ROMAN R. · 2020 to 2024
$3.1M
Vector and Host Contributions to the Regulation of E. chaffeensis Gene ExpressionR56AI070908 · NIAID · KANSAS STATE UNIVERSITY · PI GANTA, ROMAN R. · 2013 to 2013
$426k
NIAID NIH HHS R01 AI070908NIAID NIH HHS R01 AI152418NIAID NIH HHS R56 AI070908
6 · The paper itself

Abstract

Ehrlichia chaffeensis causes human monocytic ehrlichiosis by replicating within phagosomes of monocytes/macrophages. A function disruption mutation within the pathogen's ECH_0660 gene, which encodes a phage head-to-tail connector protein, resulted in the rapid clearance of the pathogen

Indexed as

MutationAnimalsBacterial ProteinsBacteriophagesEhrlichia chaffeensisEhrlichiosisEscherichia coliGene Expression Regulation, BacterialGenes, BacterialHumansImmunityIronMonocytesTicksTranscription, GeneticZincBacterial ProteinsIronZincAnaplasmataceae pathogensEhrlichia chaffeensisironmetal ion deficiencymetal ionsRickettsialestick-borne diseaseszinc

Identifiers

PMID33875547
PMCPMC8316085
OpenAlexW3153493491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.