Evidence map›Paper›PMID 33875503›Full record

ArticleBMJ case reports2021

Case of right ventricular and aortic thrombi in a patient with severe COVID-19.

Henrietta Afari, Leben Tefera, Rachel P Rosovsky

Open access · greenAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. COVID-19 and Peripheral Artery Thrombosis: A Mini Review.Current problems in cardiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Henrietta AfariHospital Medicine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA hafari@partners.org.
Leben TeferaHarrington Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Rachel P RosovskyDepartment of Hematology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Massachusetts General Hospital · USCleveland Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence suggests that novel COVID-19 is associated with increased prothrombotic state and risk of thromboembolic complications, particularly in severe disease. COVID-19 is known to predispose to both venous and arterial thrombotic disease. We describe a case of a 61-year-old woman with history of type II diabetes, hypertension and hyperlipidaemia who presented with dry cough and acute abdominal pain. She was found to have a significantly elevated D-dimer, prompting imaging that showed thrombi in her right ventricle and aorta. She had rapid clinical deterioration and eventually required tissue plasminogen activator with subsequent durable clinical improvement. This case highlights a rare co-occurrence of venous and arterial thrombi in a patient with severe COVID-19. Further studies are needed to clarify the molecular mechanism of COVID-19 coagulopathy, the utility of D-dimer to predict and stratify risk of thrombosis in COVID-19, and the use of fibrinolytic therapy in patients with COVID-19.

Indexed as

COVID-19Diabetes Mellitus, Type 2ThrombosisAortaFemaleFibrin Fibrinogen Degradation ProductsHeart VentriclesHumansMiddle AgedTissue Plasminogen ActivatorFibrin Fibrinogen Degradation Productsfibrin fragment DTissue Plasminogen ActivatorCOVID-19haematology (incl blood transfusion)venous thromboembolism

Identifiers

PMID33875503
PMCPMC8057564
OpenAlexW3156141315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.