Evidence map›Paper›PMID 33875472›Full record

ArticleInfection and immunity2021

Aim2 and Nlrp3 Are Dispensable for Vaccine-Induced Immunity against Francisella tularensis Live Vaccine Strain.

Maha Alqahtani, Zhuo Ma, Kayla Fantone, Meenakshi Malik, Chandra Shekhar Bakshi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. The immune response toFrontiers in microbiology · 2025
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Maha AlqahtaniDepartment of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, New York, USA.
Zhuo MaDepartment of Basic and Clinical Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York, USA.
Kayla FantoneDepartment of Basic and Clinical Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York, USA.
Meenakshi Malik *Department of Basic and Clinical Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York, USA.
Chandra Shekhar Bakshi *Department of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, New York, USA.
Albany College of Pharmacy and Health Sciences · USNew York Medical College · US

Funding

Repression of Inflammasome by Francisella tularensisR15AI107698 · NIAID · ALBANY COLLEGE OF PHARMACY · PI MALIK, MEENAKSHI · 2013 to 2024
$1.9M
Advancement of a Mucosal Subunit Vaccine in an Outbred Model of Respiratory TularemiaR21AI151277 · NIAID · NEW YORK MEDICAL COLLEGE · PI BAKSHI, CHANDRA SHEKHAR, REED, DOUGLAS SCOTT · 2020 to 2021
$446k
Modulation of host innate immune response by Francisella tularensisR56AI101109 · NIAID · NEW YORK MEDICAL COLLEGE · PI BAKSHI, CHANDRA SHEKHAR · 2013 to 2013
$390k
NIAID NIH HHS R15 AI107698NIAID NIH HHS R21 AI151277NIAID NIH HHS R56 AI101109
6 · The paper itself

Abstract

Francisella tularensis is a facultative, intracellular, Gram-negative bacterium that causes a fatal disease known as tularemia. Due to its extremely high virulence, ease of spread by aerosolization, and potential to be used as a bioterror agent, F. tularensis is classified by the CDC as a tier 1 category A select agent. Previous studies have demonstrated the roles of the inflammasome sensors absent in melanoma 2 (AIM2) and NLRP3 in the generation of innate immune responses to F. tularensis infection. However, contributions of both the AIM2 and NLRP3 to the development of vaccine-induced adaptive immune responses against F. tularensis are not known. This study determined the contributions of Aim2 and Nlrp3 inflammasome sensors to vaccine-induced immune responses in a mouse model of respiratory tularemia. We developed a model to vaccinate Aim2- and Nlrp3-deficient (

Indexed as

AnimalsBacterial VaccinesDisease Models, AnimalDNA-Binding ProteinsFrancisella tularensisHost-Pathogen InteractionsImmunity, HumoralImmunizationMiceMice, KnockoutMutationNLR Family, Pyrin Domain-Containing 3 ProteinTularemiaVaccines, AttenuatedVirulenceAim2 protein, mouseBacterial VaccinesDNA-Binding ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseVaccines, Attenuatedadaptive immunityAIM2Francisella tularensisimmunizationinflammasomeNLRP3

Identifiers

PMID33875472
PMCPMC8208512
OpenAlexW3155501343

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.