Evidence map›Paper›PMID 33875438›Full record

ArticleAntimicrobial agents and chemotherapy2021

Toward Chemical Validation of Leishmania infantum Ribose 5-Phosphate Isomerase as a Drug Target.

Emily A Dickie, Céline Ronin, Mónica Sá, Fabrice Ciesielski, Nathalie Trouche, Joana Tavares, Nuno Santarem, Louise L Major, Iain K Pemberton, Jane MacDougall and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Emily A DickieBiomedical Sciences Research Complex, University of St. Andrews, St. Andrews, Fife, Scotland, United Kingdom.
Céline RoninNovAliX, Biology Department, Illkirch Cedex, France.
Mónica Sái3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Fabrice CiesielskiNovAliX, Biology Department, Illkirch Cedex, France.
Nathalie TroucheNovAliX, Biology Department, Illkirch Cedex, France.
Joana Tavaresi3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Nuno Santaremi3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Louise L MajorBiomedical Sciences Research Complex, University of St. Andrews, St. Andrews, Fife, Scotland, United Kingdom.
Iain K PembertonPhoteomix Protein Discovery, IP Research Consulting, Noisy Le Grand, France.
Jane MacDougallPhoteomix Protein Discovery, IP Research Consulting, Noisy Le Grand, France.
Terry K SmithBiomedical Sciences Research Complex, University of St. Andrews, St. Andrews, Fife, Scotland, United Kingdom.
Anabela Cordeiro-da-Silvai3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Paola CiapettiNovAliX, Biology Department, Illkirch Cedex, France.
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · PTUniversity of St Andrews · GBUniversidade do Porto · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neglected tropical diseases caused by kinetoplastid parasites (Trypanosoma brucei, Trypanosoma cruzi, and

Indexed as

Leishmania infantumPharmaceutical PreparationsAmino Acid SequenceHumansRibosemonophosphatesPharmaceutical Preparationsribose-5-phosphateRibosemonophosphatesantiparasiticinhibitorLeishmania infantumleishmaniasisneglected tropical diseasesprotein crystal structureribose 5-phosphate isomerasescreeningthermal shift

Identifiers

PMID33875438
PMCPMC8373210
OpenAlexW3154863510

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.