Evidence map›Paper›PMID 33875432›Full record

ArticleAntimicrobial agents and chemotherapy2021

Impact of Amino Acid Substitutions in Region II and Helix K of Herpes Simplex Virus 1 and Human Cytomegalovirus DNA Polymerases on Resistance to Foscarnet.

Karima Zarrouk, Xiaojun Zhu, Van Dung Pham, Nathalie Goyette, Jocelyne Piret, Rong Shi, Guy Boivin

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Small Molecule Drugs Targeting Viral Polymerases.Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Karima ZarroukResearch Center in Infectious Diseases, CHU de Québec-Laval University, Quebec City, Quebec, Canada.
Xiaojun ZhuPROTEO and Institute of Integrative and Systems Biology, Laval University, Quebec City, Quebec, Canada.
Van Dung PhamPROTEO and Institute of Integrative and Systems Biology, Laval University, Quebec City, Quebec, Canada.
Nathalie GoyetteResearch Center in Infectious Diseases, CHU de Québec-Laval University, Quebec City, Quebec, Canada.
Jocelyne PiretResearch Center in Infectious Diseases, CHU de Québec-Laval University, Quebec City, Quebec, Canada.
Rong ShiPROTEO and Institute of Integrative and Systems Biology, Laval University, Quebec City, Quebec, Canada.
Guy BoivinResearch Center in Infectious Diseases, CHU de Québec-Laval University, Quebec City, Quebec, Canada.
Université Laval · CA

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (CIHR) 148361
6 · The paper itself

Abstract

Amino acid substitutions conferring resistance of herpes simplex virus 1 (HSV-1) and human cytomegalovirus (HCMV) to foscarnet (PFA) are located in the genes

Indexed as

Herpesvirus 1, HumanAmino Acid SubstitutionAntiviral AgentsCytomegalovirusDNA-Directed DNA PolymeraseDrug Resistance, ViralFoscarnetHumansMutationAntiviral AgentsDNA-Directed DNA PolymeraseFoscarnet3D modelingDNA polymerasedrug resistance mechanismsfoscarnetHCMVherpes simplex virusHSV-1human cytomegalovirusNH2-terminal domainpalm domainresistance

Identifiers

PMID33875432
PMCPMC8218610
OpenAlexW3156096663

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.