Evidence map›Paper›PMID 33875423›Full record

ArticleAntimicrobial agents and chemotherapy2021

Characterization of TMexCD3-TOprJ3, an RND-Type Efflux System Conferring Resistance to Tigecycline in Proteus mirabilis, and Its Associated Integrative Conjugative Element.

Qian Wang, Kai Peng, Yuan Liu, Xia Xiao, Zhiqiang Wang, Ruichao Li

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Outbreak of NDM-5-ProducingAntibiotics (Basel, Switzerland) · 2025
    Article
  8. Multiple Copies of Tigecycline Gene ClusterAntibiotics (Basel, Switzerland) · 2025
    Article
  9. Article
  10. Emergence of Mobilized Tigecycline Resistance Gene ClusterTransboundary and emerging diseases · 2025
    Article
  11. Article
  12. Coexistence of plasmid-mediatedMicrobiology spectrum · 2024
    Article
  13. Review
  14. Article
  15. Article
  16. First Report of Carbapenem-ResistantInfection and drug resistance · 2024
    Article
  17. Article
  18. Article
  19. Occurrence and characterization of plasmids carryingFrontiers in cellular and infection microbiology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Qian WangJiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China.
Kai PengJiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China.
Yuan LiuJiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China.
Xia XiaoJiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China.
Zhiqiang WangJiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China.
Ruichao LiJiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China.
Yangzhou University · CNMinistry of Education · MV

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence and transmission of novel antimicrobial resistance genes pose a great threat to public health globally. Recently, the plasmid-encoding RND efflux pump TMexCD1-TOprJ1 in Klebsiella pneumoniae was reported to reduce the sensitivity of multiple antimicrobials. Here, we identified a pandrug-resistant Proteus mirabilis isolate that harbored the novel

Indexed as

Klebsiella pneumoniaeProteus mirabilisAnti-Bacterial AgentsPlasmidsTigecyclineAnti-Bacterial AgentsTigecyclineefflux pumpintegrative and conjugative elements (ICEs)Proteus mirabilistigecycline resistancetmexCD3-toprJ3

Identifiers

PMID33875423
PMCPMC8218640
OpenAlexW3156452293

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.