Evidence map›Paper›PMID 33875230›Full record

ArticleBiological psychiatry2021

Reward Processing in Novelty Seekers: A Transdiagnostic Psychiatric Imaging Biomarker.

Shile Qi, Gunter Schumann, Juan Bustillo, Jessica A Turner, Rongtao Jiang, Dongmei Zhi, Zening Fu, Andrew R Mayer, Victor M Vergara, Rogers F Silva and 41 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Trial
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  6. Confound Controlled Multimodal Neuroimaging Data Fusion and Its Application to Developmental Disorders.IEEE transactions on image processing : a publication of the IEEE Signal Processing Society · 2025
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  7. Similarities and Differences in Psychology.Advances in experimental medicine and biology · 2025
    Review
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  14. Article
  15. Review
  16. Hazardous drinking and alcohol use disorders.Nature reviews. Disease primers · 2022
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

51 authors.

Shile QiTri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute Technology, and Emory University, Atlanta, Georgia; Department of Computer Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China.
Gunter SchumannCentre for Population Neuroscience and Stratified Medicine, Institute for Science and Technology of Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Juan BustilloDepartment of Psychiatry, University of New Mexico, Albuquerque, New Mexico.
Jessica A TurnerDepartment of Psychology, Georgia State University, Atlanta, Georgia.
Rongtao JiangUniversity of Chinese Academy of Sciences, Beijing, China; Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
Dongmei ZhiUniversity of Chinese Academy of Sciences, Beijing, China; Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
Zening FuTri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute Technology, and Emory University, Atlanta, Georgia.
Andrew R MayerDepartment of Psychiatry, University of New Mexico, Albuquerque, New Mexico.
Victor M VergaraTri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute Technology, and Emory University, Atlanta, Georgia.
Rogers F SilvaTri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute Technology, and Emory University, Atlanta, Georgia.
Armin IrajiTri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute Technology, and Emory University, Atlanta, Georgia.
Jiayu ChenTri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute Technology, and Emory University, Atlanta, Georgia.
Eswar DamarajuTri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute Technology, and Emory University, Atlanta, Georgia.
Xiaohong MaPsychiatric Laboratory and Mental Health Center, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, China.
Xiao YangPsychiatric Laboratory and Mental Health Center, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, China.
Michael StevensOlin Neuropsychiatry Research Center, Hartford, Connecticut.
Daniel H MathalonDepartment of Psychiatry, University of California San Francisco, San Francisco, California.
Judith M FordDepartment of Psychiatry, University of California San Francisco, San Francisco, California.
James VoyvodicDepartment of Radiology, Duke University, Durham, North Carolina.
Bryon A MuellerDepartment of Psychiatry, University of Minnesota, Minneapolis, Minnesota.
Aysenil BelgerDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Steven G PotkinDepartment of Psychiatry, University of California Irvine, Irvine, California.
Adrian PredaDepartment of Psychiatry, University of California Irvine, Irvine, California.
Chuanjun ZhuoDepartment of Psychiatric-Neuroimaging-Genetics and Morbidity Laboratory, Nankai University Affiliated Anding Hospital, Tianjin, China.
Yong XuDepartment of Humanities and Social Science, Shanxi Medical University, Taiyuan, China.
Congying ChuCentre for Population Neuroscience and Stratified Medicine, Institute for Science and Technology of Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Gareth J BarkerDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Erin Burke QuinlanCentre for Population Neuroscience and Stratified Medicine, Institute for Science and Technology of Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Sylvane DesrivièresCentre for Population Neuroscience and Stratified Medicine, Institute for Science and Technology of Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Herta FlorDepartment of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
Antoine GrigisNeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.
Hugh GaravanDepartments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont.
Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom.
Andreas HeinzDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Berlin, Germany.
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry," University Paris-Saclay, Paris, France.
Marie-Laure Paillère MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry," University Paris-Saclay, Paris, France.
Eric ArtigesInstitut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry," University Paris-Saclay, Paris, France.
Frauke NeesDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Dimitri Papadopoulos OrfanosNeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.
Tomáš PausBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital and Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Luise PoustkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, Germany.
Sarah HohmannDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Juliane H FröhnerDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Michael N SmolkaDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Henrik WalterDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Berlin, Germany.
Robert WhelanPONS Research Group, Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Humboldt University, Berlin, Germany.
Vince D CalhounTri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute Technology, and Emory University, Atlanta, Georgia; Department of Psychology, Georgia State University, Atlanta, Georgia. Electronic address: vcalhoun@ece.gatech.edu.
Jing SuiTri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute Technology, and Emory University, Atlanta, Georgia; University of Chinese Academy of Sciences, Beijing, China; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China. Electronic address: kittysj@gmail.com.
IMAGEN Consortium

Funding

Transcranial Direct Current Stimulation for Treatment of Auditory Verbal HalluciP20GM103472 · NIGMS · THE MIND RESEARCH NETWORK · PI BEDRICK, EDWARD J · 2012 to 2017
$14.3M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Pilot Project Program (PPP)P30GM122734 · NIGMS · THE MIND RESEARCH NETWORK · PI MAYER, ANDREW ROBERT · 2018 to 2022
$7.0M
Informed Data-Driven Fusion of Behavior, Brain Function, and GenesR01EB005846 · NIBIB · THE MIND RESEARCH NETWORK · PI CALHOUN, VINCE D · 2005 to 2016
$5.5M
Data-driven approaches to identify biomarkers from multimodal imaging big dataR01MH117107 · NIMH · GEORGIA STATE UNIVERSITY · PI CALHOUN, VINCE D · 2019 to 2022
$1.6M
Axon, Testosterone and Mental Health during AdolescenceR01MH085772 · NIMH · BAYCREST CENTRE FOR GERIATRIC CARE · PI PAUS, TOMAS · 2010 to 2014
$1.5M
ENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683k
Medical Research Council MR/N000390/1Medical Research Council MR/R00465X/1Medical Research Council MR/S020306/1MRF_ MRF-058-0004-RG-DESRIMRF_ MRF-058-0009-RG-DESR-C0759NIA NIH HHS R56 AG058854NIBIB NIH HHS R01 EB005846NIBIB NIH HHS U54 EB020403NIGMS NIH HHS P20 GM103472NIGMS NIH HHS P30 GM122734NIMH NIH HHS R01 MH085772NIMH NIH HHS R01 MH117107
6 · The paper itself

Abstract

backgroundDysfunctional reward processing is implicated in multiple mental disorders. Novelty seeking (NS) assesses preference for seeking novel experiences, which is linked to sensitivity to reward environmental cues.

methodsA subset of 14-year-old adolescents (IMAGEN) with the top 20% ranked high-NS scores was used to identify high-NS-associated multimodal components by supervised fusion. These features were then used to longitudinally predict five different risk scales for the same and unseen subjects (an independent dataset of subjects at 19 years of age that was not used in predictive modeling training at 14 years of age) (within IMAGEN, n ≈1100) and even for the corresponding symptom scores of five types of patient cohorts (non-IMAGEN), including drinking (n = 313), smoking (n = 104), attention-deficit/hyperactivity disorder (n = 320), major depressive disorder (n = 81), and schizophrenia (n = 147), as well as to classify different patient groups with diagnostic labels.

resultsMultimodal biomarkers, including the prefrontal cortex, striatum, amygdala, and hippocampus, associated with high NS in 14-year-old adolescents were identified. The prediction models built on these features are able to longitudinally predict five different risk scales, including alcohol drinking, smoking, hyperactivity, depression, and psychosis for the same and unseen 19-year-old adolescents and even predict the corresponding symptom scores of five types of patient cohorts. Furthermore, the identified reward-related multimodal features can classify among attention-deficit/hyperactivity disorder, major depressive disorder, and schizophrenia with an accuracy of 87.2%.

conclusionsAdolescents with higher NS scores can be used to reveal brain alterations in the reward-related system, implicating potential higher risk for subsequent development of multiple disorders. The identified high-NS-associated multimodal reward-related signatures may serve as a transdiagnostic neuroimaging biomarker to predict disease risks or severity.

Indexed as

Attention Deficit Disorder with HyperactivityMajor Depressive DisorderAdolescentAdultBiomarkersHumansMagnetic Resonance ImagingRewardYoung AdultBiomarkersADHDAttention-deficit/hyperactivity disorderMajor depressive disordersMDDNovelty seekingReward processingSchizophreniaSubstance use

Identifiers

PMID33875230
PMCPMC8322149

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.