Evidence map›Paper›PMID 33875135›Full record

ArticleeLife2021

Characterization and functional analysis of cathelicidin-MH, a novel frog-derived peptide with anti-septicemic properties.

Jinwei Chai, Xin Chen, Tiaofei Ye, Baishuang Zeng, Qingye Zeng, Jiena Wu, Barbora Kascakova, Larissa Almeida Martins, Tatyana Prudnikova, Ivana Kuta Smatanova and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
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  4. Review
  5. Insulin Resistance, Anti-inflammatory, and AntioxidantBiotechnology reports (Amsterdam, Netherlands) · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
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  14. Review
  15. Role of LL-37 in thrombotic complications in patients with COVID-19.Cellular and molecular life sciences : CMLS · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Antimicrobial Peptides: An Update on Classifications and Databases.International journal of molecular sciences · 2021
    Review
  20. FM-CATH, A Novel Cathelicidin FromFrontiers in pharmacology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Jinwei Chai *Department of Respiratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Xin Chen *Department of Respiratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Tiaofei YeDepartment of Respiratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Baishuang ZengGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Qingye ZengGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Jiena WuGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Barbora KascakovaFaculty of Science, University of South Bohemia in Ceske Budejovice, Branisovska, Czech Republic.
Larissa Almeida MartinsInstitute of Parasitology, Biology Center of the Czech Academy of Sciences, Branisovska, Czech Republic.ORCID 0000-0001-8127-6276
Tatyana PrudnikovaFaculty of Science, University of South Bohemia in Ceske Budejovice, Branisovska, Czech Republic.
Ivana Kuta SmatanovaFaculty of Science, University of South Bohemia in Ceske Budejovice, Branisovska, Czech Republic.ORCID 0000-0002-1337-9481
Michail KotsyfakisInstitute of Parasitology, Biology Center of the Czech Academy of Sciences, Branisovska, Czech Republic.ORCID 0000-0002-7526-1876
Xueqing XuGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.ORCID 0000-0002-4525-5803
Southern Medical University · CNUniversity of South Bohemia in České Budějovice · CZZhujiang Hospital · CNCzech Academy of Sciences · CZ

Funding

National Natural Science Foundation of China 31772476National Natural Science Foundation of China 31861143050National Natural Science Foundation of China 31911530077National Natural Science Foundation of China 82070038
6 · The paper itself

Abstract

Antimicrobial peptides form part of the innate immune response and play a vital role in host defense against pathogens. Here we report a new antimicrobial peptide belonging to the cathelicidin family, cathelicidin-MH (cath-MH), from the skin of

Indexed as

AnuraAmino Acid SequenceAmphibian ProteinsAnimalsAnti-Infective AgentsBase SequenceCathelicidinsPhylogenySepsisSequence AlignmentAmphibian ProteinsAnti-Infective AgentsCathelicidinsantimicrobial peptidescathelicidinimmunologyinflammationmicrohyla heymonsivogtmousesepsis

Identifiers

PMID33875135
PMCPMC8057816
OpenAlexW3154264515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.