ArticleInfectious diseases of poverty2021
Effectiveness of potential antiviral treatments in COVID-19 transmission control: a modelling study.
Article in Infectious diseases of poverty, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hospital readmissions and post-discharge all-cause mortality in COVID-19 recovered patients; A systematic review and meta-analysis.The American journal of emergency medicine · 2022Pooled it
- Primary Findings of Nationwide Home-based Test to Treat Program for COVID-19 and Influenza.medRxiv : the preprint server for health sciences · 2025Article
- Insights from a community-based survey on factors influencing acceptance and uptake of Paxlovid (nirmatrelvir and ritonavir) as a COVID-19 antiviral medication in Singapore.BMC public health · 2024Article
- Model-based analysis of the incidence trends and transmission dynamics of COVID-19 associated with the Omicron variant in representative cities in China.BMC public health · 2023Article
- Dynamic and classifier-based model SARS-CoV-2 Omicron spillover risk assessment in China.Fundamental research · 2023Article
- Epidemiological characteristics and transmission dynamics of the COVID-19 outbreak in Hohhot, China: a time-varying SQEIAHR model analysis.Frontiers in public health · 2023Article
- Impact of vaccination and non-pharmacological interventions on COVID-19: a review of simulation modeling studies in Asia.Frontiers in public health · 2023Review
- Optimal control strategies of SARS-CoV-2 Omicron supported by invasive and dynamic models.Infectious diseases of poverty · 2022Article
- Mathematical Models Supporting Control of COVID-19.China CDC weekly · 2022Article
- ComputingInfectious Disease Modelling · 2022Article
- An Easy-to-Use Public Health-Driven Method (the Generalized Logistic Differential Equation Model) Accurately Simulated COVID-19 Epidemic in Wuhan and Correctly Determined the Early Warning Time.Frontiers in public health · 2022Article
- Model-Based Evaluation of Transmissibility and Intervention Measures for a COVID-19 Outbreak in Xiamen City, China.Frontiers in public health · 2022Article
- Promising Antiviral Activity ofPharmaceuticals (Basel, Switzerland) · 2021Article
- Containing the Transmission of COVID-19: A Modeling Study in 160 Countries.Frontiers in medicine · 2021Article
Corrections and comments
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Authors and funding
25 authors.
Funding
Abstract
backgroundNovel coronavirus disease 2019 (COVID-19) causes an immense disease burden. Although public health countermeasures effectively controlled the epidemic in China, non-pharmaceutical interventions can neither be maintained indefinitely nor conveniently implemented globally. Vaccination is mainly used to prevent COVID-19, and most current antiviral treatment evaluations focus on clinical efficacy. Therefore, we conducted population-based simulations to assess antiviral treatment effectiveness among different age groups based on its clinical efficacy.
methodsWe collected COVID-19 data of Wuhan City from published literature and established a database (from 2 December 2019 to 16 March 2020). We developed an age-specific model to evaluate the effectiveness of antiviral treatment in patients with COVID-19. Efficacy was divided into three types: (1) viral activity reduction, reflected as transmission rate decrease [reduction was set as v (0-0.8) to simulate hypothetical antiviral treatments]; (2) reduction in the duration time from symptom onset to patient recovery/removal, reflected as a 1/γ decrease (reduction was set as 1-3 days to simulate hypothetical or real-life antiviral treatments, and the time of asymptomatic was reduced by the same proportion); (3) fatality rate reduction in severely ill patients (f
resultsComparing the simulation results of combination and single medication therapy s, all four age groups showed better results with combination medication. When 1/γ = 2 and v = 0.4, age group 2 had the highest TAR reduction rate (98.48%, 56.01-0.85%). When 1/γ = 2, z = 0.3, and v = 0.1, age group 1 had the highest reduction rate of f (83.08%, 0.71-0.12%).
conclusionsAntiviral treatments are more effective in COVID-19 transmission control than in mortality reduction. Overall, antiviral treatments were more effective in younger age groups, while older age groups showed higher COVID-19 prevalence and mortality. Therefore, physicians should pay more attention to prevention of viral spread and patients deaths when providing antiviral treatments to patients of older age groups.
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