Evidence map›Paper›PMID 33874989›Full record

ArticleBMC research notes2021

Genetic variants of the EGFR ligand-binding domain and their association with structural alterations in Arab cancer patients.

Maryam Marzouq, Ali Nairouz, Noureddine Ben Khalaf, Sonia Bourguiba-Hachemi, Raed Quaddorah, Dana Ashoor, M Dahmani Fathallah

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Maryam MarzouqDepartment of Life Sciences, Health Biotechnology Program, College of Graduate Studies, Arabian Gulf University, PO Box 26671, Manama, Kingdom of Bahrain.
Ali NairouzDepartment of Life Sciences, Health Biotechnology Program, College of Graduate Studies, Arabian Gulf University, PO Box 26671, Manama, Kingdom of Bahrain.
Noureddine Ben KhalafDepartment of Life Sciences, Health Biotechnology Program, College of Graduate Studies, Arabian Gulf University, PO Box 26671, Manama, Kingdom of Bahrain.
Sonia Bourguiba-HachemiDepartment of Life Sciences, Health Biotechnology Program, College of Graduate Studies, Arabian Gulf University, PO Box 26671, Manama, Kingdom of Bahrain.
Raed QuaddorahDepartment of Life Sciences, Health Biotechnology Program, College of Graduate Studies, Arabian Gulf University, PO Box 26671, Manama, Kingdom of Bahrain.
Dana AshoorDepartment of Life Sciences, Health Biotechnology Program, College of Graduate Studies, Arabian Gulf University, PO Box 26671, Manama, Kingdom of Bahrain.
M Dahmani FathallahDepartment of Life Sciences, Health Biotechnology Program, College of Graduate Studies, Arabian Gulf University, PO Box 26671, Manama, Kingdom of Bahrain. d.fathallah@agu.edu.bh.
Arabian Gulf University · BH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to identify novel genetic variants in the CR2 extracellular domain of the epidermal growth factor receptor (EGFR) in healthy individuals and patients with six different types of adenocarcinoma, in Arabian peninsula populations. It also aimed to investigate the effects of these variants on the EGFR structure and their eventual relevance to tumorigenesis.

resultsWe detected seven new EGFR genetic variants in 168 cancer patients and 114 controls. A SNP rs374670788 was more frequent in bladder cancer but not significantly associated to. However, a missense mutation (V550M) was significantly associated to colon, ovary, lung, bladder and thyroid cancer samples (p < 0.05). Three mutations (H590R, E602K and T605T) were found in the heterozygous form only in colon cancer patients. Genomic analysis of the synonymous mutation (G632G) showed that the T/A genotype could be associated to thyroid cancer in Arab patients (p < 0.05). An additional novel SNP rs571064657 was observed in control individuals. Computational analysis of the genetic variants revealed a reduction in the stabilization of the EGFR tethered form for both V550M and the common R521K variant with low energetic state (- ∆∆G). Molecular interactions analysis suggested that these mutations might affect the receptor's function and promote tumorigenesis.

Indexed as

AdenocarcinomaLung NeoplasmsArabsErbB ReceptorsFemaleHumansLigandsMutationEGFR protein, humanErbB ReceptorsLigandsAdenocarcinomaArabian Peninsula populationArabsCR1/CR2 EGFR domainsEGFR proteinEGFR R521K polymorphismMissense mutationSingle nucleotide polymorphism

Identifiers

PMID33874989
PMCPMC8054381
OpenAlexW3152784017

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.