ArticleCritical care (London, England)2021
The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study.
Article in Critical care (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04321265 (Outcomes and Prognostic Factors in Coronavirus Disease), which is not on this map. Cited by 87 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Outcomes and Prognostic Factors in Coronavirus Disease (COVID-19) in Very Old Intensive Care Patients
Who cites it
87 citing papers in PubMed, 3 syntheses or guidelines pooled it, 186 citations in OpenAlex.
- The devastating trio of sarcopenia, frailty, and COVID-19 - A systematic review and meta-analysis.Clinical nutrition ESPEN · 2022Pooled it
- Methods of Assessing Frailty in the Critically Ill: A Systematic Review of the Current Literature.Gerontology · 2022Pooled it
- Association of Frailty With the Risk of Mortality and Resource Utilization in Elderly Patients in Intensive Care Units: A Meta-Analysis.Frontiers in medicine · 2021Pooled it
- End-of-life decision-making in very old critically ill patients.European geriatric medicine · 2026Review
- The Influence of Older Age on RBC Transfusion Decisions in ICU Patients.Critical care medicine · 2026Observational
- Invasive ventilation and mortality in critically ill nonagenarians: a retrospective cohort study.European journal of medical research · 2026Article
- [Experiences from SARS-CoV-2 pandemic at UKSH Lübeck].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026Article
- Three-year functional, physical, and mental health outcomes after critical COVID-19: A prospective multicentre cohort study.PloS one · 2026Article
- Age and grit in prioritising intensive care: - a mixed-methods approach of normative challenges.BMC medical ethics · 2025Article
- Frailty and comorbidity in COVID-19 patients with and without ICU admission restrictions: a retrospective observational study.Journal of anesthesia, analgesia and critical care · 2025Article
- "Geriatric patients in Argentinean ICUs: admission, care patterns, outcomes and healthcare system implications".BMC geriatrics · 2025Observational
- Genetic Evidence on the Role of Blood Phytosterols in Frailty: A Mendelian Randomization Study.Food science & nutrition · 2025Article
- Prognosis of Nonagenarian ICU Patients A Bayesian analysis of prospective European studies.Annals of intensive care · 2025Article
- The pictorial fit-frail scale: a novel tool for frailty assessment in critically ill older adults.BMC geriatrics · 2025Article
- Major psychiatric comorbidity among the critically ill: a multi-centred cohort study in Queensland.BMC psychiatry · 2025Article
- Clinical Characteristics and Prognosis of Older Patients with Coronavirus Disease 2019 Requiring Mechanical Ventilation.Journal of personalized medicine · 2024Article
- Caring for frail patients in the ICU: a multidimensional approach.Intensive care medicine · 2024Article
- Clinical Manifestations and Outcomes of Older Patients with COVID-19: A Comprehensive Review.Tuberculosis and respiratory diseases · 2024Article
- Impact of frailty on long-term survival in patients discharged alive from hospital after an ICU admission with COVID-19.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024Article
- Impact of frailty, biomarkers and basic biochemical parameters on outcomes of comatose patients in status epilepticus: a single-center prospective pilot study.BMC neurology · 2024Article
27 more citing papers are in PubMed but not listed here.
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Authors and funding
28 authors at 20 institutions in 17 countries.
Funding
Abstract
backgroundThe COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due to the large numbers of patients being admitted into hospitals. One of the potential prognostic indicators in patients with COVID-19 is frailty. The degree of frailty could be used to assist both the triage into intensive care, and decisions regarding treatment limitations. Our study sought to determine the interaction of frailty and age in elderly COVID-19 ICU patients.
methodsA prospective multicentre study of COVID-19 patients ≥ 70 years admitted to intensive care in 138 ICUs from 28 countries was conducted. The primary endpoint was 30-day mortality. Frailty was assessed using the clinical frailty scale. Additionally, comorbidities, management strategies and treatment limitations were recorded.
resultsThe study included 1346 patients (28% female) with a median age of 75 years (IQR 72-78, range 70-96), 16.3% were older than 80 years, and 21% of the patients were frail. The overall survival at 30 days was 59% (95% CI 56-62), with 66% (63-69) in fit, 53% (47-61) in vulnerable and 41% (35-47) in frail patients (p < 0.001). In frail patients, there was no difference in 30-day survival between different age categories. Frailty was linked to an increased use of treatment limitations and less use of mechanical ventilation. In a model controlling for age, disease severity, sex, treatment limitations and comorbidities, frailty was independently associated with lower survival.
conclusionFrailty provides relevant prognostic information in elderly COVID-19 patients in addition to age and comorbidities. Trial registration Clinicaltrials.gov: NCT04321265 , registered 19 March 2020.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.