Trial reportChiropractic & manual therapies2021
The effect of chiropractic care on infantile colic: results from a single-blind randomised controlled trial.
Trial report in Chiropractic & manual therapies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02595515 (The Effect of Chiropractic Treatment of Infantile Colic. A Randomized, Controlled Trial), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Chiropractic Treatment of Infantile Colic. A Randomized, Controlled Trial
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Colic and sleep outcomes of nonpharmacological intervention in infants with infantile colic: systematic review and metaanalysis.Revista da Associacao Medica Brasileira (1992) · 2023Pooled it
- Identifying potential treatment effect modifiers of the effectiveness of chiropractic care to infants with colic through prespecified secondary analyses of a randomised controlled trial.Chiropractic & manual therapies · 2021Trial
- Midwives' perspectives on assessing and managing mothers' distress related to excessive infant crying in Japan: a qualitative content analysis study.BMC pregnancy and childbirth · 2025Article
- Autheem therapy for young Saudi infants: the whys and the impacts.BMC pediatrics · 2025Article
- Exploring Manual Interventions for Infantile Colic: A Scoping Review of the Evidence.Children (Basel, Switzerland) · 2025Review
- Chiropractic Care in Children: A Review of Evidence and Safety.Clinical pediatrics · 2025Review
- Comparison of Effectiveness of Manual Therapy for Infant Crying: systematic review and meta-analysis of randomized controlled trials.Journal of pharmacopuncture · 2023Review
- Chiropractic care and research priorities for the pediatric population: a cross-sectional survey of Quebec chiropractors.Chiropractic & manual therapies · 2023Article
- Cry analysis for early detection of infantile colic: Integrating behavioral and acoustic cry patterns using machine learning.Digital healthArticle
- [Prevalence of Infantile Colic: Experience of the Working Group on Disorders of Gut-Brain Axis of the Latin American Society of Paediatric Gastroenterology, Hepatology and Nutrition (LASPGHAN)].Acta gastroenterologica LatinoamericanaArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChiropractic care is commonly used to treat infantile colic. However large trials with parental blinding are missing. Therefore, the purpose of this study is to evaluate the effect of chiropractic care on infantile colic.
methodThis is a multicenter, single-blind randomized controlled trial conducted in four Danish chiropractic clinics, 2015-2019. Information was distributed in the maternity wards and by maternal and child health nurses. Children aged 2-14 weeks with unexplained excessive crying were recruited through home visits and randomized (1:1) to either chiropractic care or control group. Both groups attended the chiropractic clinic twice a week for 2 weeks. The intervention group received chiropractic care, while the control group was not treated. The parents were not present in the treatment room and unaware of their child's allocation. The primary outcome was change in daily hours of crying before and after treatment. Secondary outcomes were changes in hours of sleep, hours being awake and content, gastrointestinal symptoms, colic status and satisfaction. All outcomes were based on parental diaries and a final questionnaire.
resultsOf 200 recruited children, 185 completed the trial (treatment group n = 96; control group n = 89). Duration of crying in the treatment group was reduced by 1.5 h compared with 1 h in the control group (mean difference - 0.6, 95% CI - 1.1 to - 0.1; P = 0.026), but when adjusted for baseline hours of crying, age and chiropractic clinic, the difference was not significant (P = 0.066). The proportion obtaining a clinically important reduction of 1 h of crying was 63% in the treatment group and 47% in the control group (p = 0.037), and NNT was 6.5. We found no effect on any of the secondary outcomes.
conclusionExcessive crying was reduced by half an hour in favor of the group receiving chiropractic care compared with the control group, but not at a statistically significant level after adjustments. From a clinical perspective, the mean difference between the groups was small, but there were large individual differences, which emphasizes the need to investigate if subgroups of children, e.g. those with musculoskeletal problems, benefit more than others from chiropractic care.
trial registrationClinical Trials NCT02595515 , registered 2 November 2015.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.