ArticlePaediatrics and international child health2021
Blood transfusion and mortality in children with severe anaemia in a malaria-endemic region.
Article in Paediatrics and international child health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06075108 (P-KIDs CARE), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
P-KIDs CARE: An Intervention to Address Health Systems Delays to Care for Injured Children in Tanzania
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Facilitators and barriers to blood and blood product accessibility and use in sub-Saharan Africa: a systematic review.Frontiers in health services · 2026Pooled it
- Clinical Effect of Microneedle Injection Combined with Blood Transfusion in the Treatment of Severe Anemia Complicated with Vitiligo under Regenerative Medical Technology.BioMed research international · 2022Trial
- Implementation of a Prospective Birth Cohort for Newborn Screening and Early Linkage to Comprehensive Sickle Cell Disease Care in a Low-Resource Setting.International journal of neonatal screening · 2026Article
- Facilitators and barriers to adherence to severe malaria treatment guidelines in children at Mbale Regional Referral Hospital, Uganda: a health workers' perspective.Malaria journal · 2026Article
- Blood group antigens and malaria susceptibility.Frontiers in cellular and infection microbiology · 2025Review
- Severe malaria intervention status in Nigeria: workshop meeting report.Malaria journal · 2024Article
- Mortality by Admission Diagnosis in Children 1-60 Months of Age Admitted to a Tertiary Care Government Hospital in Malawi.The American journal of tropical medicine and hygiene · 2023Article
- Uptake of Plasmodium chabaudi hemozoin drives Kupffer cell death and fuels superinfections.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundIn children in sub-Saharan Africa, severe anaemia (SA) is an important cause of mortality, and malaria is a primary cause. The World Health Organization (WHO) recommends blood transfusion for all children with haemoglobin (Hb) <4 g/dL and for those with Hb 4-6 g/dL with signs of instability. In sub-Saharan Africa, evidence of the effect on mortality of transfusion in children with SA with and without malaria is mixed.
aimTo determine in children with and without malaria whether receipt of transfusion was associated with lower mortality at WHO transfusion thresholds.
methodsThis was a retrospective cohort study of 1761 children with SA (Hb ≤6 g/dL) admitted to Kamuzu Central Hospital in Malawi. In those whose Hb was 4-6 g/dL, mortality was compared by transfusion, stratified by haemoglobin, malaria status and signs of instability.
resultsChildren with profound anaemia (Hb <4 g/dL) and malaria were the only subgroup who had a significant decrease in the odds of in-hospital death if they received a transfusion (OR 0.43,
conclusionsThis study suggests that transfusion of children with profound anaemia and malaria may confer increased in-hospital survival. An understanding of the factors associated with mortality from SA will allow for interventions to prioritise the provision of limited blood.
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