ArticleJournal of biomechanics2021
Levodopa facilitates improvements in gait kinetics at the hip, not the ankle, in individuals with Parkinson's disease.
Article in Journal of biomechanics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Sarcopenia, body composition, physical performance, and clinical features in Parkinson's disease: a cross-sectional comparative study.Frontiers in endocrinology · 2026Article
- Effects of anti-parkinsonian medication on gait during internal and external rhythmic auditory cueing in PD.Frontiers in human neuroscience · 2026Article
- A New Methodological Approach Integrating Motion Capture and Pressure-Sensitive Gait Data to Assess Functional Mobility in Parkinson's Disease: A Two-Phase Study.Sensors (Basel, Switzerland) · 2025Article
- The comparison of gait disorders among different motor subtypes in Parkinson's disease patients during the early and middle stages.Clinical parkinsonism & related disorders · 2025Article
- Individual joint contributions to forward propulsion are not related to stability during walking in young or older adults.Gait & posture · 2024Article
- 3D Kinematics Quantifies Gait Response to Levodopa earlier and to a more Comprehensive Extent than the MDS-Unified Parkinson's Disease Rating Scale in Patients with Motor Complications.Movement disorders clinical practice · 2024Article
- Visual feedback improves propulsive force generation during treadmill walking in people with Parkinson disease.Journal of biomechanics · 2024Article
- Acclimatization of force production during walking in persons with Parkinson's disease.Journal of biomechanics · 2023Article
- Clinical Disease Severity Mediates the Relationship between Stride Length and Speed and the Risk of Falling in Parkinson's Disease.Journal of personalized medicine · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Parkinson's disease symptoms impair gait, limit mobility, and reduce independence. Levodopa improves muscle activation, strength, and coordination; thus, facilitating increased step length, but few studies have evaluated the underlying forces associated with medication-induced gait improvements. Here, we assess the effects of levodopa on gait kinetics in persons with Parkinson's disease. Over two sessions, 13 participants with Parkinson's disease walked on a treadmill while both optimally medicated and after a 12-hour medication withdrawal. Walking was analyzed for spatiotemporal parameters, ranges of motion, anterior-posterior ground reaction forces, joint torques, and powers using an instrumented treadmill and motion capture system. When on medication, participants increased gait speed by significantly improving step length (p = .009) and time (p = .004). Peak propulsive force (p = .001) and hip flexion torques (p = .003) increased with medication while hip extensor and ankle plantarflexor torques did not. While differences in joint power were not significantly different, the optimal medication condition showed medium to large effects, with the largest effect at the hip (d
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