Evidence map›Paper›PMID 33873099›Full record

ArticleRespiratory medicine2021

Bronchodilator reversibility testing in post-COVID-19 patients undergoing pulmonary rehabilitation.

Mauro Maniscalco, Pasquale Ambrosino, Salvatore Fuschillo, Silvia Stufano, Alessandro Sanduzzi, Maria Gabriella Matera, Mario Cazzola

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Respiratory medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05770440 (Impact of COVID-19 on Lung Function in COPD Patients), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05770440 unknown statusnot on this mapstarted 2023, after this paper: background citation

Impact of COVID-19 on Lung Function in COPD Patients

TypeobservationalSponsorFundacio d'Investigacio en Atencio Primaria Jordi Gol i GurinaRan2023 to 2025Enrolled250ConditionsCOPD, COVID-19
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Bronchodilator Response in Post-COVID-19 Patients Undergoing Pulmonary Rehabilitation.Respiration; international review of thoracic diseases · 2024
    Article
  7. Article
  8. Implementing a Multidisciplinary Post-COVID Clinic in a Small Community Environment.Archives of rehabilitation research and clinical translation · 2023
    Article
  9. Review
  10. The Hidden Pandemic of COVID-19-Induced Organizing Pneumonia.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  11. Article
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Mauro ManiscalcoIstituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy.
Pasquale AmbrosinoIstituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy.
Salvatore FuschilloIstituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy.
Silvia StufanoIstituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy.
Alessandro SanduzziSection of Respiratory Diseases, Department of Clinical Medicine and Surgery, Monaldi Hospital, University of Naples Federico II, Naples, Italy.
Maria Gabriella MateraUnit of Pharmacology, Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Mario CazzolaUnit of Respiratory Medicine, Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy. Electronic address: mario.cazzola@uniroma2.it.
Istituti Clinici Scientifici Maugeri · ITOspedale Monaldi · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe usefulness of bronchodilators in coronavirus diseases 2019 (COVID-19) survivors is still uncertain, especially for patients with a concomitant obstructive lung disease. We aimed at verifying the level of bronchodilator reversibility in COVID-19 patients undergoing multidisciplinary pulmonary rehabilitation after the acute phase.

methodsWe enrolled 105 consecutive patients referring to the Pulmonary Rehabilitation Unit of Istituti Clinici Scientifici Maugeri Spa SB, IRCCS of Telese Terme, Benevento, Italy after being discharged from the COVID-19 acute care ward and after recovering from acute COVID-19 pneumonia. All subjects performed a spirometry before and after inhalation of salbutamol 400 μg to determine the bronchodilation response within 48 h of admission to the unit.

resultsAll patients had suffered from a moderate to severe COVID-19, classified 3 or 4 according to the WHO classification, Seventeen patients had concomitant obstructive lung disease (14 suffering from COPD and 3 from asthma). FEV

conclusionsThis study suggests that a treatment with bronchodilators must always be taken into consideration in post-COVID-19 patients because it can induce a functional improvement that, even if small, can facilitate the breathing of these patients.

Indexed as

Administration, InhalationAgedBronchodilator AgentsCOVID-19FemaleForced Expiratory VolumeHumansLungMaleMiddle AgedPandemicsPulmonary Disease, Chronic ObstructiveRespiratory Function TestsSARS-CoV-2Bronchodilator AgentsBronchodilatorsChronic diseaseCOVID-19DisabilityOutcomeRehabilitation

Identifiers

PMID33873099
PMCPMC8041746
OpenAlexW3154237389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.