Evidence map›Paper›PMID 33872847›Full record

ArticleAddictive behaviors2021

Risk factors for alcohol, marijuana, and cigarette polysubstance use during adolescence and young adulthood: A 7-year longitudinal study of youth at high risk for smoking escalation.

Natania A Crane, Scott A Langenecker, Robin J Mermelstein

Open access · greenAbstract read
In one paragraph

Article in Addictive behaviors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
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  4. Multilevel Correlates of Same Day Poly-Product Use/Co-Use among Adolescents Who Use Tobacco and Cannabis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Article
  5. Polysubstance use and mental health among young adults.Canadian journal of public health = Revue canadienne de sante publique · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Natania A CraneDepartment of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street (M/C 912) Chicago, Illinois 60612, United States. Electronic address: ncrane3@uic.edu.
Scott A LangeneckerDepartment of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street (M/C 912) Chicago, Illinois 60612, United States; Department of Psychiatry, University of Utah, 501 Chipeta Way, Salt Lake City, UT 84108, United States.
Robin J MermelsteinInstitute for Health Research and Policy and Psychology Department, University of Illinois at Chicago, 1747 West Roosevelt Road (M/C 275) Chicago, Illinois 60608, United States.
Roosevelt University · USUniversity of Illinois Chicago · USUniversity of Utah · US

Funding

Social-Emotional Contexts of Adolescent Smoking PatternsP01CA098262 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MERMELSTEIN, ROBIN J. · 2004 to 2014
$26.3M
Brain-Behavior Markers of Reward and Cannabis Abuse Risk in Young AdultsK23DA048132 · NIDA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CRANE, NATANIA A · 2020 to 2024
$954k
Neurocognitive, Affective and Psychosocial Correlates of Adolescent Substance UseF31DA038388 · NIDA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CRANE, NATANIA A · 2014 to 2015
$83k
NCI NIH HHS P01 CA098262NIDA NIH HHS F31 DA038388NIDA NIH HHS K23 DA048132NIDA NIH HHS L30 DA049275
6 · The paper itself

Abstract

introductionAlcohol, nicotine, and marijuana are the three most widely used substances among adolescents and young adults, with co-use of multiple substances being common. Few longitudinal studies have examined risk factors of alcohol, marijuana, and nicotine poly-substance use. We examined frequency of alcohol, marijuana, and cigarette poly-substance use over time and how key risk factors contribute to this substance use during adolescence and young adulthood.

methodsParticipants (N = 1263 9th and 10th graders) were oversampled for ever-smoking a cigarette at baseline from 16 Chicago-area high schools between 2004 and 2006. Many participants progressed to heavier cigarette use, as well as alcohol and marijuana use over time. Participants completed questionnaires assessing substance use and psychosocial factors at baseline, 6-, 15-, 24-, 33-months, and 5-, 6-, and 7-years.

resultsLongitudinal multi-level models demonstrated that at baseline and over time, more depression symptoms, more anxiety symptoms, negative mood regulation expectancies, and lower grade point average (GPA) were each associated with more poly-substance use over time. In addition, there were a number of interaction effects of gender (e.g., depression was related to substance use in males) and developmental stage moderated these relationships.

conclusionsDepression, anxiety, negative mood regulation expectancies, and GPA all significantly influence both initial and longitudinal levels of substance use across adolescence and young adulthood. Our findings underscore the importance of identifying and treating youth with depression and anxiety symptoms, as well as providing resources early for those struggling in school in order to help with substance use prevention and intervention efforts.

Indexed as

CannabisMarijuana SmokingTobacco ProductsAdolescentAdultAlcohol DrinkingChicagoFemaleHumansLongitudinal StudiesMaleRisk FactorsSmokingYoung AdultAlcoholAnxietyCigarettesDepressionMarijuanaNicotine

Identifiers

PMID33872847
PMCPMC8120743
OpenAlexW3146960241

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.