Evidence map›Paper›PMID 33872837›Full record

ArticleWorld neurosurgery2021

Hippocampal and Orbitofrontal Theta Band Coherence Diminishes During Conflict Resolution.

Austin M Tang, Kuang-Hsuan Chen, Roberto Martin Del Campo-Vera, Rinu Sebastian, Angad S Gogia, George Nune, Charles Y Liu, Spencer Kellis, Brian Lee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Austin M TangDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA. Electronic address: austint@usc.edu.
Kuang-Hsuan ChenDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.
Roberto Martin Del Campo-VeraDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.
Rinu SebastianDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.
Angad S GogiaDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.
George NuneDepartment of Neurology, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA; USC Neurorestoration Center, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.
Charles Y LiuDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA; USC Neurorestoration Center, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA; Department of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
Spencer KellisDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA; USC Neurorestoration Center, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA; Department of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA; Tianqiao and Chrissy Chen Brain-Machine Interface Center, Chen Institute for Neuroscience, California Institute of Technology, Pasadena, California, USA.
Brian LeeDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA; USC Neurorestoration Center, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA; Department of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
University of Southern California · US

Funding

Mentored Career DevelopmentKL2TR001854 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Elizabeth Rhea Erwin Burner, Amy Elizabeth West · 2016 to 2026
$9.0M
NCATS NIH HHS KL2 TR001854
6 · The paper itself

Abstract

objectiveCoherence between the hippocampus and other brain structures has been shown with the theta frequency (3-8 Hz). Cortical decreases in theta coherence are believed to reflect response accuracy efficiency. However, the role of theta coherence during conflict resolution is poorly understood in noncortical areas. In this study, coherence between the hippocampus and orbitofrontal cortex (OFC) was measured during a conflict resolution task. Although both brain areas have been previously implicated in the Stroop task, their interactions are not well understood.

methodsNine patients were implanted with stereotactic electroencephalography contacts in the hippocampus and OFC. Local field potential data were sampled throughout discrete phases of a Stroop task. Coherence was calculated for hippocampal and OFC contact pairs, and coherence spectrograms were constructed for congruent and incongruent conditions. Coherence changes during cue processing were identified using a nonparametric cluster-permutation t test. Group analysis was conducted to compare overall theta coherence changes among conditions.

resultsIn 6 of 9 patients, decreased theta coherence was observed only during the incongruent condition (P < 0.05). Congruent theta coherence did not change from baseline. Group analysis showed lower theta coherence for the incongruent condition compared with the congruent condition (P < 0.05).

conclusionsTheta coherence between the hippocampus and OFC decreased during conflict. This finding supports existing theories that theta coherence desynchronization contributes to improved response accuracy and processing efficiency during conflict resolution. The underlying theta coherence observed between the hippocampus and OFC during conflict may be distinct from its previously observed role in memory.

Indexed as

Conflict, PsychologicalAdultDrug Resistant EpilepsyElectrodes, ImplantedElectroencephalographyFemaleHippocampusHumansMaleMiddle AgedNegotiatingPrefrontal CortexTheta RhythmYoung AdultCoherenceConflict processingOrbitofrontal cortexStereotactic electroencephalography hippocampusStroopTheta

Identifiers

PMID33872837
PMCPMC8338769
OpenAlexW3153702934

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.