Evidence map›Paper›PMID 33872772›Full record

ArticleNanomedicine : nanotechnology, biology, and medicine2021

Superparamagnetic iron oxide-gold nanoparticles conjugated with porous coordination cages: Towards controlled drug release for non-invasive neuroregeneration.

Muzhaozi Yuan, Tian-Hao Yan, Jialuo Li, Zhifeng Xiao, Yu Fang, Ya Wang, Hong-Cai Zhou, Jean-Philippe Pellois

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomedicine : nanotechnology, biology, and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Muzhaozi YuanJ. Mike Walker '66 Department of Mechanical Engineering, Texas A&M University, College Station, TX, USA. Electronic address: muzhaozi.yuan@tamu.edu.
Tian-Hao YanDepartment of Chemistry, Texas A&M University, College Station, TX, USA. Electronic address: thyan426@tamu.edu.
Jialuo LiDepartment of Chemistry, Texas A&M University, College Station, TX, USA. Electronic address: lijialuo@tamu.edu.
Zhifeng XiaoDepartment of Chemistry, Texas A&M University, College Station, TX, USA. Electronic address: xiao@tamu.edu.
Yu FangState Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan, P. R. China. Electronic address: yu.fang@hnu.edu.cn.
Ya WangJ. Mike Walker '66 Department of Mechanical Engineering, Texas A&M University, College Station, TX, USA; Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, USA; Department of Biomedical Engineering, Texas A&M University, College Station, TX, USA. Electronic address: ya.wang@tamu.edu.
Hong-Cai ZhouDepartment of Chemistry, Texas A&M University, College Station, TX, USA. Electronic address: zhou@chem.tamu.edu.
Jean-Philippe PelloisDepartment of Chemistry, Texas A&M University, College Station, TX, USA; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA. Electronic address: pellois@tamu.edu.

Funding

Mechanisms and optimization of endosomal escape for delivery applicationsR01GM110137 · NIGMS · TEXAS A&M AGRILIFE RESEARCH · PI PELLOIS, JEAN-PHILIPPE · 2015 to 2022
$2.3M
NIGMS NIH HHS R01 GM110137
6 · The paper itself

Abstract

This paper reports a smart intracellular nanocarrier for sustainable and controlled drug release in non-invasive neuroregeneration. The nanocarrier is composed by superparamagnetic iron oxide-gold (SPIO-Au) core-shell nanoparticles (NPs) conjugated with porous coordination cages (PCCs) through the thiol-containing molecules as bridges. The negatively charged PCC-2 and positively charged PCC-3 are compared for intracellular targeting. Both types result in intracellular targeting via direct penetration across cellular membranes. However, the pyrene (Py)-PEG-SH bridge enabled functionalization of SPIO-Au NPs with PCC-3 exhibits higher interaction with PC-12 neuron-like cells, compared with the rhodamine B (RhB)-PEG-SH bridge enabled case and the stand-alone SPIO-Au NPs. With neglectable toxicities to PC-12 cells, the proposed SPIO-Au-RhB(Py)-PCC-2(3) nanocarriers exhibit effective drug loading capacity of retinoic acid (RA) at 13.505 μg/mg of RA/NPs within 24 h. A controlled release of RA is achieved by using a low-intensity 525 nm LED light (100% compared to 40% for control group within 96 h).

Indexed as

Drug CarriersFerric CompoundsGoldNanoparticlesTretinoinAnimalsDelayed-Action PreparationsNerve RegenerationPC12 CellsPorosityRatsDelayed-Action PreparationsDrug CarriersFerric Compoundsferric oxideGoldTretinoinIntracellular targetingNon-invasive neuroregenerationPorous coordination cagesSuperparamagnetic iron oxide-gold nanoparticlesSustainable and controlled drug release

Identifiers

PMID33872772
PMCPMC8238818

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.