Evidence map›Paper›PMID 33872546›Full record

ArticleAnnals of the American Thoracic Society2021

Tissue Plasminogen Activator in Critically Ill Adults with COVID-19.

David J Douin, Shahzad Shaefi, Samantha K Brenner, Shruti Gupta, Isabel Park, Franklin L Wright, Kusum S Mathews, Lili Chan, Hanny Al-Samkari, Sarah Orfanos and 2 more

Registry-linked trialOpen access · hybridAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of the American Thoracic Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04343898 (Study of the Treatment and Outcomes in Critically Ill Patients With COVID-19), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04343898 completednot on this map

Study of the Treatment and Outcomes in Critically Ill Patients With COVID-19

TypeobservationalSponsorBrigham and Women's HospitalRan2020 to 2023Enrolled5,154ConditionsCoronavirus InfectionArmsNo intervention
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Fibrinolytic system and COVID-19: From an innovative view of epithelial ion transport.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023
    Review
  3. Article
  4. Article
  5. The suboptimal fibrinolytic response in COVID-19 is dictated by high PAI-1.Journal of thrombosis and haemostasis : JTH · 2022
    Article
  6. Review
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

David J DouinUniversity of Colorado School of Medicine Aurora, Colorado.ORCID 0000-0002-5215-6854
Shahzad ShaefiBeth Israel Deaconess Medical Center Boston, Massachusetts.
Samantha K BrennerHackensack University Medical Center Hackensack, New Jersey.
Shruti GuptaBrigham and Women's Hospital, Harvard Medical School Boston, Massachusetts.ORCID 0000-0002-5747-2151
Isabel ParkBrigham and Women's Hospital, Harvard Medical School Boston, Massachusetts.
Franklin L WrightUniversity of Colorado School of Medicine Aurora, Colorado.
Kusum S MathewsIcahn School of Medicine at Mount Sinai New York, New York.ORCID 0000-0002-8810-2794
Lili ChanIcahn School of Medicine at Mount Sinai New York, New York.
Hanny Al-SamkariMassachusetts General Hospital Boston, Massachusetts.
Sarah OrfanosRutgers Robert Wood Johnson Medical School New Brunswick, New Jersey.
Jared RadbelRutgers Robert Wood Johnson Medical School New Brunswick, New Jersey.
David E LeafBrigham and Women's Hospital, Harvard Medical School Boston, Massachusetts.ORCID 0000-0001-7875-090X
Brigham and Women's Hospital · USIcahn School of Medicine at Mount Sinai · USRutgers, The State University of New Jersey · USUniversity of Colorado Denver · USBeth Israel Deaconess Medical Center · USHackensack University Medical Center · USMassachusetts General Hospital · US

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI PANOS G. GEORGOPOULOS · 1988 to 2026
$47.4M
Deferoxamine for the Prevention of Acute Kidney InjuryR01DK125786 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI LEAF, DAVID EVAN · 2020 to 2024
$3.5M
Precision Medicine Approach to Vitamin D3 Administration in Critical IllnessR01HL144566 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LEAF, DAVID EVAN · 2019 to 2022
$1.8M
Role of Macrophage Efferocytosis in Ozone-Induced ARDSK08ES031678 · NIEHS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI RADBEL, JARED M. · 2020 to 2024
$1.1M
Anesthesiology Mentored Research TrainingT32GM135169 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Susan L Ingram, Vesna Jevtovic-Todorovic · 2021 to 2026
$1.0M
Improving risk prediction of adverse outcomes in hemodialysis patients by incorporating non-traditional risk factorsK23DK124645 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHAN, LILI · 2021 to 2025
$952k
Sepsis and the benefits of permissive hypoxiaK08GM134220 · NIGMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SHAEFI, SHAHZAD · 2019 to 2022
$775k
Optimizing ED to ICU triage decisions for critically ill patients in respiratory distressK23HL130648 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MATHEWS, KUSUM SARA · 2016 to 2021
$744k
Proteomic Analysis of Postoperative Delirium from a randomized trial in Older Patients undergoing Cardiac Surgery exposed to Intraoperative Normoxia versus Hyperoxia: A Nested Case-Control StudyR03AG060179 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SHAEFI, SHAHZAD · 2018 to 2019
$263k
NHLBI NIH HHS K23 HL130648NHLBI NIH HHS R01 HL144566NIA NIH HHS R03 AG060179NIDDK NIH HHS K23 DK124645NIDDK NIH HHS R01 DK125786NIEHS NIH HHS K08 ES031678NIEHS NIH HHS P30 ES005022NIGMS NIH HHS K08 GM134220NIGMS NIH HHS T32 GM135169
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

COVID-19 Drug TreatmentTissue Plasminogen ActivatorAdultCritical IllnessHumansTissue Plasminogen Activator

Identifiers

PMID33872546
PMCPMC8641829
OpenAlexW3154818093

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.