Evidence map›Paper›PMID 33872477›Full record

SynthesisTrends in psychiatry and psychotherapy

Neuroprogression in post-traumatic stress disorder: a systematic review.

Thyago Antonelli-Salgado, Luis Francisco Ramos-Lima, Cristiane Dos Santos Machado, Ryan Michael Cassidy, Taiane de Azevedo Cardoso, Flávio Kapczinski, Ives Cavalcante Passos

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Trends in psychiatry and psychotherapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thyago Antonelli-SalgadoPrograma de Pós-Graduação em Psiquiatria e Ciências do Comportamento, Departamento de Psiquiatria, Escola de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Laboratório de Psiquiatria Molecular, Centro de Pesquisa Experimental (CPE), Centro de Pesquisa Clínica (CPC), Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil. Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Porto Alegre, RS, Brazil.
Luis Francisco Ramos-LimaPrograma de Pós-Graduação em Psiquiatria e Ciências do Comportamento, Departamento de Psiquiatria, Escola de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Cristiane Dos Santos MachadoPrograma de Pós-Graduação em Psiquiatria e Ciências do Comportamento, Departamento de Psiquiatria, Escola de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Laboratório de Psiquiatria Molecular, Centro de Pesquisa Experimental (CPE), Centro de Pesquisa Clínica (CPC), Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil. Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Porto Alegre, RS, Brazil.
Ryan Michael CassidyMcGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Taiane de Azevedo CardosoInstituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Porto Alegre, RS, Brazil.
Flávio KapczinskiInstituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Porto Alegre, RS, Brazil. Mood Disorders Program, Department of Psychiatry and Behavioral Neuroscience, McMaster University, Hamilton, ON, Canada.
Ives Cavalcante PassosPrograma de Pós-Graduação em Psiquiatria e Ciências do Comportamento, Departamento de Psiquiatria, Escola de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Laboratório de Psiquiatria Molecular, Centro de Pesquisa Experimental (CPE), Centro de Pesquisa Clínica (CPC), Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil. Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Porto Alegre, RS, Brazil.

Funding

Center for Clinical and Translational Sciences (CCTS)TL1TR000369 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$1.9M
A novel lateral hypothalamic neurocircuit enhances rewarding aspects of feedingF30DA047030 · NIDA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CASSIDY, RYAN M · 2019 to 2019
$33k
NCATS NIH HHS TL1 TR000369NIDA NIH HHS F30 DA047030
6 · The paper itself

Abstract

introductionNeuroprogression has been proposed as the pathological rewiring of the brain that takes place in parallel with clinical and neurocognitive deterioration in the course of psychiatric disorders. This study aims to review the biological underpinnings and clinical outcomes related to neuroprogression in post-traumatic stress disorder (PTSD).

methodsWe performed a systematic review by searching PubMed, Embase, and Web of Science for articles published between January 1, 1960, and January 6, 2020. Inclusion criteria were met when articles assessed brain changes, neurocognition, functioning, inflammation, oxidative stress, and neurotrophins in patients with PTSD. Narrative review articles, case reports, and preclinical studies were excluded.

resultsA total of 965 abstracts were identified and 15 articles were included in our systematic review. It seems that for a subset of patients whose symptoms worsen or are maintained at a high intensity there is a progressive change in the frontal lobe, especially the prefrontal cortex, and worsening of both neurocognition (verbal memory and facial recognition) and functioning (physical, psychological, social and environmental).

conclusionAlthough current findings associate progressive reduction in frontal lobe size with neurocognitive impairment, further research is needed to characterize PTSD as a neuroprogressive disorder.

Indexed as

Stress Disorders, Post-TraumaticBrainHumansneuroimagingNeuroprogressionPTSD

Identifiers

PMID33872477
PMCPMC8638708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.