Evidence map›Paper›PMID 33872323›Full record

SynthesisPloS one2021

Predicting poor outcomes in children aged 1-12 with respiratory tract infections: A systematic review.

George Edwards, Louise Newbould, Charlotte Nesbitt, Miranda Rogers, Rebecca L Morris, Alastair D Hay, Stephen M Campbell, Gail Hayward

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

George EdwardsNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-0048-4178
Louise NewbouldSocial Policy Research Unit, University of York, York, United Kingdom.ORCID 0000-0001-5234-4866
Charlotte NesbittNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
Miranda RogersNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
Rebecca L MorrisDivision of Population Health, NIHR Greater Manchester Patient Safety Translational Research Centre, School of Health Sciences, University of Manchester, Manchester, United Kingdom.
Alastair D HayCentre for Academic Primary Care, Bristol Medical School: Population Health Sciences, University of Bristol, Bristol, United Kingdom.
Stephen M CampbellDivision of Population Health, NIHR Greater Manchester Patient Safety Translational Research Centre, School of Health Sciences, University of Manchester, Manchester, United Kingdom.
Gail HaywardNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
University of Oxford · GBManchester Academic Health Science Centre · GBUniversity of Bristol · GBUniversity of York · GB

Funding

Department of Health
6 · The paper itself

Abstract

backgroundDemand for NHS services is high and rising. In children respiratory tract infections (RTI) are the most common reason for consultation with primary care. Understanding which features are associated with good and poor prognosis with RTI will help develop interventions to support parents manage illness.

aimTo identify symptoms, signs, and investigation results associated with good and poor prognosis, and clinical decision making in children aged 1-12 years with RTI symptoms, at home and presenting to ambulatory care. DESIGN AND

settingSystematic literature review.

methodsWe searched MEDLINE, EMBASE, Cinahl, Web of Science and the Cochrane database of systematic reviews for studies of children aged 1 to 12 years with a RTI or related condition reporting symptoms, signs and investigation results associated with prognostic outcomes. Quality was assessed using the QUIPS tool.

resultsWe included 27 studies which included 34802 children and measured 192 factors. Nine studies explored future outcomes and the remainder explored clinical management from the initial consultation with the health services. None were conducted in a home setting. Respiratory signs, vomiting, fever, dehydration and tachycardia at the initial contact were associated with future hospitalisation. Little evidence was available for other outcomes.

conclusionSome evidence is available to clinicians to stratify risk of, future hospitalisation, but not of other prognostic outcomes. There is little evidence available to parents to identify children at risk of poor prognosis. Research is needed into whether poor prognosis can be predicted by parents in the home.

Indexed as

ChildChild, PreschoolClinical Decision-MakingDisease ProgressionFemaleHospitalizationHumansInfantMalePrognosisRespiratory Tract InfectionsRisk Assessment

Identifiers

PMID33872323
PMCPMC8055026
OpenAlexW3156268608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.