Evidence map›Paper›PMID 33871975›Full record

ReviewACS biomaterials science & engineering2021

Methods of Generating Dielectrophoretic Force for Microfluidic Manipulation of Bioparticles.

Elyahb A Kwizera, Mingrui Sun, Alisa M White, Jianrong Li, Xiaoming He

Abstract readReview
In one paragraph

Review in ACS biomaterials science & engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Isolation Techniques of Micro/Nano-Scaled Species for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. [Recent advances in responsive isolation, release and clinical application of circulating tumor cells].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Elyahb A KwizeraFischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States.
Mingrui SunDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio 43210, United States.
Alisa M WhiteFischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States.
Jianrong LiDepartment of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, United States.
Xiaoming HeFischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States.ORCID 0000-0003-0125-6086

Funding

A novel lactic acid bacteria-based norovirus vaccineR01AI123661 · NIAID · OHIO STATE UNIVERSITY · PI BOYAKA, PROSPER N, HE, XIAOMING · 2016 to 2020
$3.0M
Nanotechnology for targeted therapy and fundamental understanding oftherapeutic resistance in triple negative breast cancerR01CA243023 · NCI · UNIV OF MARYLAND, COLLEGE PARK · PI HE, XIAOMING · 2020 to 2024
$2.0M
Nanotechnology enabled targeting of p53 deficiency in human cancerR01CA206366 · NCI · UNIV OF MARYLAND, COLLEGE PARK · PI HE, XIAOMING, LU, XIONGBIN · 2016 to 2020
$1.9M
Microfluidic encapsulation of ovarian follicles for biomimetic 3D culture andcryopreservationR01EB023632 · NIBIB · UNIV OF MARYLAND, COLLEGE PARK · PI HE, XIAOMING · 2017 to 2020
$1.6M
NCI NIH HHS R01 CA206366NCI NIH HHS R01 CA243023NIAID NIH HHS R01 AI123661NIBIB NIH HHS R01 EB023632
6 · The paper itself

Abstract

Manipulation of microscale bioparticles including living cells is of great significance to the broad bioengineering and biotechnology fields. Dielectrophoresis (DEP), which is defined as the interactions between dielectric particles and the electric field, is one of the most widely used techniques for the manipulation of bioparticles including cell separation, sorting, and trapping. Bioparticles experience a DEP force if they have a different polarization from the surrounding media in an electric field that is nonuniform in terms of the intensity and/or phase of the electric field. A comprehensive literature survey shows that the DEP-based microfluidic devices for manipulating bioparticles can be categorized according to the methods of creating the nonuniformity via patterned microchannels, electrodes, and media to generate the DEP force. These methods together with the theory of DEP force generation are described in this review, to provide a summary of the methods and materials that have been used to manipulate various bioparticles for various specific biological outcomes. Further developments of DEP-based technologies include identifying materials that better integrate with electrodes than current popular materials (silicone/glass) and improving the performance of DEP manipulation of bioparticles by combining it with other methods of handling bioparticles. Collectively, DEP-based microfluidic manipulation of bioparticles holds great potential for various biomedical applications.

Indexed as

Microfluidic Analytical TechniquesMicrofluidicsCell SeparationElectrophoresisLab-On-A-Chip Devicescell manipulationDEPdielectrophoresismicrofluidicspatternsorting

Identifiers

PMID33871975
PMCPMC8205986

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.