ArticleUnited European gastroenterology journal2021
Mortality in acute pancreatitis with persistent organ failure is determined by the number, type, and sequence of organ systems affected.
Article in United European gastroenterology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Thymosin alpha 1 alleviates inflammation and prevents infection in patients with severe acute pancreatitis through immune regulation: a systematic review and meta-analysis.Frontiers in immunology · 2025Pooled it
- Time-series analysis of gene expression identifies of FKBP4 as a novel protective factor in severe acute pancreatitis-associated myocardial injury.Biochemistry and biophysics reports · 2026Article
- Hypertriglyceridemic Acute Pancreatitis With Concomitant Retrocecal Appendicitis: A Case Report.Clinical case reports · 2026Article
- Correlation between imaging features (edematous and necrotizing) and clinical severity (mild, moderately severe, and severe) in acute pancreatitis: an updated perspective.Abdominal radiology (New York) · 2026Review
- RAGE Signalling in Acute Inflammatory Disorders: Therapeutic Potential of Natural Products.Biomolecules · 2026Review
- Divergent associations of phosphate levels with organ failure between ICU and non-ICU populations with acute pancreatitis.BMC gastroenterology · 2026Article
- The effect of serum lipase levels on clinical severity scores and mortality in acute pancreatitis: a retrospective cohort study.BMC gastroenterology · 2026Article
- New-onset persistent organ failure predicts adverse outcomes in patients with severe acute pancreatitis.World journal of gastroenterology · 2026Article
- Beyond triglyceride clearance: rethinking hypertriglyceridemia-associated acute pancreatitis in the apoC-III era.Gastroenterology report · 2026Review
- Blood urea nitrogen to albumin ratio as a robust predictor of in-hospital mortality in patients with predicted severe acute pancreatitis: a retrospective multicenter observational study.International journal of surgery (London, England) · 2026Observational
- Beyond the Pancreas: The Gut Microbiota in Acute Pancreatitis - From Mechanisms to Therapeutic Perspectives.Clinical and experimental gastroenterology · 2026Review
- Clinical evaluation of probe capture-based targeted next-generation sequencing in suspected infected pancreatic necrosis: a prospective pilot diagnostic study.BMC infectious diseases · 2025Article
- Acute pancreatitis: Translating early mechanisms to bedside management.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Review
- Translational Pharmaco-Nutritional Approaches in the Management of Clinical Acute Pancreatitis-A Narrative Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Quest for an accurate and reproducible prognostic biomarker of severe acute pancreatitis: have we finally found it?Hepatobiliary surgery and nutrition · 2025Article
- Automated machine learning for early prediction of systemic inflammatory response syndrome in acute pancreatitis.BMC medical informatics and decision making · 2025Article
- Morbidity and Mortality Predictors of Acute Respiratory Failure in Acute Pancreatitis: A Cohort Study Conducted in Vietnam.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Visceral obesity anthropometric indicators as predictors of acute pancreatitis severity.Frontiers in medicine · 2025Article
- AI-powered innovations in pancreatitis imaging: a comprehensive literature synthesis.Abdominal radiology (New York) · 2025Review
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31 authors at 20 institutions in 10 countries.
Funding
Abstract
backgroundPersistent organ failure (POF) is the strongest determinant of mortality in acute pancreatitis (AP). There is a paucity of data regarding the impact of different POF attributes on mortality and the role of different characteristics of systemic inflammatory response syndrome (SIRS) in the risk of developing POF.
objectiveWe aimed to assess the association of POF dynamic features with mortality and SIRS characteristics with POF.
methodsWe studied 1544 AP subjects prospectively enrolled at 22 international centers (APPRENTICE consortium). First, we estimated the association of onset, duration, and maximal score of SIRS with POF. Then, we evaluated the risk of mortality based on POF onset, duration, number, type, and sequence of organs affected. Analyses were adjusted for potential confounders.
results58% had SIRS, 11% developed POF, and 2.5% died. Early SIRS, persistent SIRS, and maximal SIRS score ≥ 3 were independently associated with higher risk of POF (p < 0.05). Mortality risk in POF was higher with two (33%, odds ratio [OR] = 10.8, 3.3-34.9) and three (48%, OR = 20.2, 5.9-68.6) organs failing, in comparison to single POF (4%). In subjects with multiple POF, mortality was higher when the cardiovascular and respiratory systems failed first or concurrently as compared to when the renal system failed first or concurrently with other organ (p < 0.05). In multivariate regression model, the number and sequence of organs affected in POF were associated with mortality (p < 0.05). Onset and duration of POF had no impact mortality.
conclusionIn AP patients with POF, the risk of mortality is influenced by the number, type, and sequence of organs affected. These results are useful for future revisions of AP severity classification systems.
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