ArticleBiometrical journal. Biometrische Zeitschrift2021
Combining biomarkers by maximizing the true positive rate for a fixed false positive rate.
Article in Biometrical journal. Biometrische Zeitschrift, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Directional drift in biologically meaningful vector planes: A proposed geometric framework for early detection of subthreshold disease.PloS one · 2026Article
- Conditional concordance-assisted learning under matched case-control design for combining biomarkers for population screening.Statistics in medicine · 2023Article
- LINEAR BIOMARKER COMBINATION FOR CONSTRAINED CLASSIFICATION.Annals of statistics · 2022Article
- Development of a Multiprotein Classifier for the Detection of Early Stage Ovarian Cancer.Cancers · 2022Article
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Authors and funding
4 authors.
Funding
Abstract
Biomarkers abound in many areas of clinical research, and often investigators are interested in combining them for diagnosis, prognosis, or screening. In many applications, the true positive rate (TPR) for a biomarker combination at a prespecified, clinically acceptable false positive rate (FPR) is the most relevant measure of predictive capacity. We propose a distribution-free method for constructing biomarker combinations by maximizing the TPR while constraining the FPR. Theoretical results demonstrate desirable properties of biomarker combinations produced by the new method. In simulations, the biomarker combination provided by our method demonstrated improved operating characteristics in a variety of scenarios when compared with alternative methods for constructing biomarker combinations. Thus, use of our method could lead to the development of better biomarker combinations, increasing the likelihood of clinical adoption.
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