Evidence map›Paper›PMID 33871799›Full record

ReviewNeurochemical research2021

Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer's Disease.

Md Sahab Uddin, Dewan Md Sumsuzzman, Philippe Jeandet, Tapan Behl, Abdur Rauf, Md Shah Amran, Ghulam Md Ashraf

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurochemical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 5 countries.

Md Sahab UddinDepartment of Pharmacy, Southeast University, Dhaka, Bangladesh. msu-neuropharma@hotmail.com.ORCID http://orcid.org/0000-0002-0805-7840
Dewan Md SumsuzzmanDepartment of Pharmacy, Southeast University, Dhaka, Bangladesh.
Philippe JeandetResearch Unit "Induced Resistance and Plant Bioprotection", Faculty of Sciences, EA 4707, SFR Condorcet FR CNRS 3417, University of Reims Champagne-Ardenne, PO Box 1039, 51687, Reims Cedex 2, France.
Tapan BehlChitkara College of Pharmacy, Chitkara University, Chandigarh, Punjab, India.
Abdur RaufDepartment of Chemistry, University of Swabi, Anbar, Khyber Pakhtunkhwa, Pakistan.
Md Shah AmranDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh.
Ghulam Md AshrafPre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Centre National de la Recherche Scientifique · FRChitkara University · INKing Abdulaziz University · SASoutheast University · BDUniversity of Dhaka · BDUniversity of Swabi · PKUttara University · BD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is one of the crucial causative factors for progressive dementia. Neuropathologically, AD is characterized by the extracellular accumulation of amyloid beta plaques and intracellular neurofibrillary tangles in cortical and limbic regions of the human brain. The circadian system is one of the many affected physiological processes in AD, the dysfunction of which may reflect in the irregularity of the sleep/wake cycle. The interplay of circadian and sleep disturbances inducing AD progression is bidirectional. Sleep-associated pathological alterations are frequently evident in AD. Understanding the interrelation between circadian disruption and AD may allow for earlier identification of AD pathogenesis as well as better suited approaches and potential therapies to combat dementia. In this article, we examine the existing literature related to the molecular mechanisms of the circadian clock and interacting mechanisms of circadian disruption and AD pathogenesis.

Indexed as

alpha-SynucleinAlzheimer DiseaseAmyloid beta-PeptidesAnimalsCircadian RhythmGastrointestinal MicrobiomeHumansMelatoninSleepSleep Disorders, Circadian Rhythmtau Proteinsalpha-SynucleinAmyloid beta-PeptidesMelatonintau ProteinsAlzheimer’s diseaseAmyloid betaCircadian disruptionNeurofibrillary tanglesRapid eye movementSleep deprivationSlow-wave sleep

Identifiers

PMID33871799
OpenAlexW3155845169

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.