Evidence map›Paper›PMID 33871795›Full record

ArticleResearch on child and adolescent psychopathology2021

Dispositional Negative Emotionality in Childhood and Adolescence Predicts Structural Variation in the Amygdala and Caudal Anterior Cingulate During Early Adulthood: Theoretically and Empirically Based Tests.

Benjamin B Lahey, Kendra E Hinton, Leah Burgess, Francisco C Meyer, Bennett A Landman, Victoria Villata-Gil, Xiaochan Yang, Paul J Rathouz, Brooks Applegate, David H Zald

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research on child and adolescent psychopathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Benjamin B LaheyDepartment of Public Health Sciences (MC 2000), University of Chicago, 5841 S. Maryland Avenue, Chicago, IL, 606036, USA. blahey@uchicago.edu.ORCID 0000-0002-0385-9676
Kendra E HintonVanderbilt University, Nashville, TN, USA.
Leah BurgessVanderbilt University, Nashville, TN, USA.
Francisco C MeyerVanderbilt University, Nashville, TN, USA.
Bennett A LandmanVanderbilt University, Nashville, TN, USA.
Victoria Villata-GilVanderbilt University, Nashville, TN, USA.
Xiaochan YangDepartment of Public Health Sciences (MC 2000), University of Chicago, 5841 S. Maryland Avenue, Chicago, IL, 606036, USA.
Paul J RathouzUniversity of Texas At Austin, Austin, TX, USA.
Brooks ApplegateWestern Michigan University, Kalamazoo, MI, USA.
David H ZaldVanderbilt University, Nashville, TN, USA.
Vanderbilt University · USChicago Department of Public Health · USThe University of Texas at Austin · USWestern Michigan University · US

Funding

RDoC Constructs: Neural Substrates, Heritability, and Relation to PsychopathologyR01MH098098 · NIMH · VANDERBILT UNIVERSITY · PI LAHEY, BENJAMIN B, ZALD, DAVID HAROLD · 2012 to 2015
$4.4M
NIMH NIH HHS R01 MH098098
6 · The paper itself

Abstract

Substantial evidence implicates the amygdala and related structures in the processing of negative emotions. Furthermore, neuroimaging evidence suggests that variations in amygdala volumes are related to trait-like individual differences in neuroticism/negative emotionality, although many questions remain about the nature of such associations. We conducted planned tests of the directional prediction that dispositional negative emotionality measured at 10-17 years using parent and youth ratings on the Child and Adolescent Dispositions Scale (CADS) would predict larger volumes of the amygdala in adulthood and conducted exploratory tests of associations with other regions implicated in emotion processing. Participants were 433 twins strategically selected for neuroimaging during wave 2 from wave 1 of the Tennessee Twins Study (TTS) by oversampling on internalizing and/or externalizing psychopathology risk. Controlling for age, sex, race-ethnicity, handedness, scanner, and total brain volume, youth-rated negative emotionality positively predicted bilateral amygdala volumes after correction for multiple testing. Each unit difference of one standard deviation (SD) in negative emotionality was associated with a .12 SD unit difference in larger volumes of both amygdalae. Parent-rated negative emotionality predicted greater thickness of the left caudal/dorsal anterior cingulate cortex (β = 0.28). Associations of brain structure with negative emotionality were not moderated by sex. These results are striking because dispositions assessed at 10-17 years of age were predictive of grey matter volumes measured 12-13 years later in adulthood. Future longitudinal studies should examine the timing of amygdala/cingulate associations with dispositional negative emotionality to determine when these associations emerge during development.

Indexed as

AmygdalaGyrus CinguliAdolescentAdultBrainChildEmotionsHumansPersonalityAmygdalaCaudal anterior cingulateNegative emotionalityNeuroticism

Identifiers

PMID33871795
PMCPMC10288797
OpenAlexW3154720044

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.