Evidence map›Paper›PMID 33871784›Full record

ArticleGeroScience2021

Left-ventricular hypertrophy in 18-month-old donor rat hearts was not associated with graft dysfunction in the early phase of reperfusion after cardiac transplantation-gene expression profiling.

Sevil Korkmaz-Icöz, Deniz Akca, Shiliang Li, Sivakkanan Loganathan, Paige Brlecic, Mihály Ruppert, Alex Ali Sayour, Andreas Simm, Maik Brune, Tamás Radovits and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 0 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Sevil Korkmaz-IcözLaboratory of Cardiac Surgery, Department of Cardiac Surgery, University Hospital Heidelberg, 69120, Heidelberg, Germany. korkmaz@uni-heidelberg.de.
Deniz AkcaLaboratory of Cardiac Surgery, Department of Cardiac Surgery, University Hospital Heidelberg, 69120, Heidelberg, Germany.
Shiliang LiLaboratory of Cardiac Surgery, Department of Cardiac Surgery, University Hospital Heidelberg, 69120, Heidelberg, Germany.
Sivakkanan LoganathanLaboratory of Cardiac Surgery, Department of Cardiac Surgery, University Hospital Heidelberg, 69120, Heidelberg, Germany.
Paige BrlecicLaboratory of Cardiac Surgery, Department of Cardiac Surgery, University Hospital Heidelberg, 69120, Heidelberg, Germany.
Mihály RuppertLaboratory of Cardiac Surgery, Department of Cardiac Surgery, University Hospital Heidelberg, 69120, Heidelberg, Germany.
Alex Ali SayourLaboratory of Cardiac Surgery, Department of Cardiac Surgery, University Hospital Heidelberg, 69120, Heidelberg, Germany.
Andreas SimmDepartment of Cardiac Surgery, University Hospital Halle (Saale), 06120, Halle, Germany.
Maik BruneDepartment of Medicine I and Clinical Chemistry, Heidelberg University Hospital, 69120, Heidelberg, Germany.
Tamás RadovitsHeart and Vascular Center, Semmelweis University, 1122, Budapest, Hungary.
Matthias KarckLaboratory of Cardiac Surgery, Department of Cardiac Surgery, University Hospital Heidelberg, 69120, Heidelberg, Germany.
Gábor SzabóLaboratory of Cardiac Surgery, Department of Cardiac Surgery, University Hospital Heidelberg, 69120, Heidelberg, Germany.
University Hospital Heidelberg · DEHeidelberg University · DESemmelweis University · HUUniversity Hospital in Halle · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of hearts with left-ventricular (LV) hypertrophy (LVH) could offer an opportunity to extend the donor pool for cardiac transplantation. We assessed the effects of LVH in 18-month-old spontaneously hypertensive stroke-prone (SHRSP) donor rats and following transplantation. In donors, cardiac function and structural alterations were assessed. Then, the hearts were transplanted into young normotensive-rats. We evaluated LV graft function 1 h after transplantation. The myocardial expression of 92 genes involved in apoptosis, inflammation, and oxidative-stress was profiled using PCR-array. Compared to controls, SHRSP-rats developed LVH, had increased LV systolic performance (slope of the end-diastolic pressure-volume (PV) relationship: 1.6±0.2 vs 0.8±0.1mmHg/μl, p<0.05) accompanied by diastolic dysfunction [prolonged time constant of LV pressure decay (Tau: 15.8±0.6 vs 12.3±0.5ms) and augmented diastolic stiffness (LV end-diastolic PV relationship: 0.103±0.012 vs 0.045±0.006mmHg/ml), p<0.05]. They presented ECG changes, myocardial fibrosis, and increased nitrotyrosine immunoreactivity and plasma troponin-T and creatine kinase-CM levels. After transplantation, even though the graft contractility was better in SHRSP rats compared to controls, the adverse impact of ischemia/reperfusion-injury on contractility was not altered (E

Indexed as

Heart TransplantationAnimalsGene Expression ProfilingHumansHypertrophyRatsReperfusionTissue DonorsAgeing;Gene expressionHeart transplantation;Left-ventricular hypertrophy;Spontaneously hypertensive stroke-prone rats;

Identifiers

PMID33871784
PMCPMC8492839
OpenAlexW3153260763

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.