ArticleMolecular biology and evolution2021
Genomic Basis of Striking Fin Shapes and Colors in the Fighting Fish.
Article in Molecular biology and evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 55 citations in OpenAlex.
- Comparative Genomic Screening Identifies Developmental Constraint Loci Underscoring the Phenotypic Evolution of Syngnathids.Integrative zoology · 2026Article
- Acute Toxic Impact of Cyclophosphamide on the Metabolic Organs of Siamese Fighting Fish (Toxics · 2026Article
- Evolutionary Analysis of Vertebrate KCNH Voltage-Gated Potassium Channels and Spatial Expression ofJournal of developmental biology · 2026Article
- Transposons drove the evolution of a male sex-determining gene from a female gene with deep introgression across cichlids.Science advances · 2026Article
- Evolutionary analysis of vertebrate KCNH voltage-gated potassium channels and their expression in zebrafish embryos.bioRxiv : the preprint server for biology · 2026Article
- Development of Cells Repository ofAnimals : an open access journal from MDPI · 2026Article
- Role of multi-omics in aquaculture genetics and breeding: current status and future perspective.Science China. Life sciences · 2025Review
- Chromosome-level genome assembly and annotation of Japanese anchovy (Engraulis japonicus).Scientific data · 2025Article
- Genome-Wide Association Studies (GWAS) and Transcriptome Analysis Reveal Male Heterogametic Sex-Determining Regions and Candidate Genes in Northern Snakeheads (International journal of molecular sciences · 2024Article
- Phylogenomic analyses of all species of swordtail fishes (genus Xiphophorus) show that hybridization preceded speciation.Nature communications · 2024Article
- Expansion and Functional Diversification of Long-Wavelength-Sensitive Opsin in Anabantoid Fishes.Journal of molecular evolution · 2024Article
- The reference genome of Macropodus opercularis (the paradise fish).Scientific data · 2024Article
- Combination of GWAS and FMolecular genetics and genomics : MGG · 2023Article
- The GRN concept as a guide for evolutionary developmental biology.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2023Article
- Genetic manipulation of betta fish.bioRxiv : the preprint server for biology · 2023Article
- Genetic manipulation of betta fish.Frontiers in genome editing · 2023Article
- Linked selection, differential introgression and recombination rate variation promote heterogeneous divergence in a pair of yellow croakers.Molecular ecology · 2022Article
- Platyfish bypass the constraint of the caudal fin ventral identity in teleosts.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- The genetic architecture of phenotypic diversity in the Betta fish (Science advances · 2022Article
- A chromosome-level genome assembly of chia provides insights into high omega-3 content and coat color variation of its seeds.Plant communications · 2022Article
Corrections and comments
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Authors and funding
18 authors at 7 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resolving the genomic basis underlying phenotypic variations is a question of great importance in evolutionary biology. However, understanding how genotypes determine the phenotypes is still challenging. Centuries of artificial selective breeding for beauty and aggression resulted in a plethora of colors, long-fin varieties, and hyper-aggressive behavior in the air-breathing Siamese fighting fish (Betta splendens), supplying an excellent system for studying the genomic basis of phenotypic variations. Combining whole-genome sequencing, quantitative trait loci mapping, genome-wide association studies, and genome editing, we investigated the genomic basis of huge morphological variation in fins and striking differences in coloration in the fighting fish. Results revealed that the double tail, elephant ear, albino, and fin spot mutants each were determined by single major-effect loci. The elephant ear phenotype was likely related to differential expression of a potassium ion channel gene, kcnh8. The albinotic phenotype was likely linked to a cis-regulatory element acting on the mitfa gene and the double-tail mutant was suggested to be caused by a deletion in a zic1/zic4 coenhancer. Our data highlight that major loci and cis-regulatory elements play important roles in bringing about phenotypic innovations and establish Bettas as new powerful model to study the genomic basis of evolved changes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.