Evidence map›Paper›PMID 33871602›Full record

Trial reportThe American journal of clinical nutrition2021

Improved diet quality is associated with decreased concentrations of inflammatory markers in adults with uncontrolled asthma.

Unni C Nygaard, Lan Xiao, Kari C Nadeau, Kinjal M Hew, Nan Lv, Carlos A Camargo, Peg Strub, Jun Ma

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01725945 (A Pilot Study of the DASH Diet in Not-Well-Controlled Adult Asthma), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01725945 nacompletednot on this map

A Pilot Study of the DASH Diet in Not-Well-Controlled Adult Asthma

TypeinterventionalSponsorPalo Alto Medical FoundationRan2013 to 2014Enrolled90ConditionsAsthma, HypertensionArmsDietary Approaches to Stop Hypertension dietary pattern
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Wildfire and asthma - The prospective interventions.The World Allergy Organization journal · 2025
    Review
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  7. Article
  8. Article
  9. Article
  10. Article
  11. Observational
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  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Unni C NygaardSean N Parker Center for Allergy and Asthma Research, Division of Pulmonary and Critical Care Medicine and Division of Allergy, Immunology and Rheumatology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-2955-9970
Lan XiaoDepartment of Medicine, Stanford University, Palo Alto, CA, USA.
Kari C NadeauSean N Parker Center for Allergy and Asthma Research, Division of Pulmonary and Critical Care Medicine and Division of Allergy, Immunology and Rheumatology, Stanford University, Stanford, CA, USA.
Kinjal M HewSean N Parker Center for Allergy and Asthma Research, Division of Pulmonary and Critical Care Medicine and Division of Allergy, Immunology and Rheumatology, Stanford University, Stanford, CA, USA.
Nan LvInstitute of Health Research and Policy, University of Illinois at Chicago, Chicago, IL, USA.
Carlos A CamargoDepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Peg StrubDepartment of Allergy, Asthma and Immunology, Kaiser Permanente San Francisco, San Francisco, CA, USA.
Jun MaDepartment of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Stanford University · USUniversity of Illinois Chicago · USHarvard University · USKaiser Permanente San Francisco Medical Center · USNorwegian Institute of Public Health · NO

Funding

A Pilot Study of the DASH Diet in Not-Well-Controlled Adult AsthmaR34HL108753 · NHLBI · PALO ALTO MEDICAL FOUNDATION RES INST · PI MA, JUN · 2012 to 2013
$691k
NHLBI NIH HHS R34 HL108753
6 · The paper itself

Abstract

backgroundAsthma has become one of the major public health challenges, and recent studies show promising clinical benefits of dietary interventions, such as the Dietary Approaches to Stop Hypertension (DASH) diet.

objectiveThe objective of this study was to examine whether changes in diet quality are associated with changes in inflammatory markers important in asthma pathophysiology.

methodsIn this exploratory study in patients with poorly controlled asthma participating in a randomized controlled trial of a DASH intervention study, changes in concentrations of a broad panel of serum proteins (51-plex Luminex assay, Affymetrix) were determined, and their relation to diet quality (DASH score) assessed by combining data of both intervention and usual-care control groups. Second, the relation between the serum proteins, other biomarkers of inflammation and nutrition, and Asthma Control Questionnaire (ACQ) was assessed.

resultsDuring the first 3 mo, diet quality (DASH scores) were inversely associated (P < 0.05, false discovery rate P < 0.09) with serum concentrations of a large number serum proteins, reflecting not only general proinflammatory markers such as IL-1β, transforming growth factor α (TGF-α), and IL-6 (r = -0.31 to -0.39) but also a number of proteins associated with asthmatic conditions, specifically several T-helper (Th) 2 (Th2; r = -0.29 to -0.34) and Th17 (r = -0.4) associated cytokines and growth factors. Monokine induced by gamma/chemokine (C-X-C motif) ligand 9 (CXCL9) (MIG/CXCL9), a T-cell attractant induced by IFN-γ previously linked to asthma exacerbations, appeared to be the marker most consistently associated with DASH diet quality for the entire 6-mo study period (r = -0.40 and -0.30 for 0-3 and 3-6 mo, respectively, and standardized coefficient loadings -0.13 in the partial least squares analyses). Decreases in 19 serum protein concentrations were also correlated with improved asthma control during the 6-mo study period.

conclusionsOur data in adult patients with poorly controlled asthma suggest that dietary changes, like the introduction of DASH, may have beneficial effects on reducing inflammatory status. This trial was registered at http://www.clinicaltrials.gov as NCT01725945.

Indexed as

AdultAgedAsthmaBiomarkersBlood ProteinsCytokinesDietFemaleHumansInflammationMaleMiddle AgedYoung AdultBiomarkersBlood ProteinsCytokinesasthmablood proteinscytokinesDASH dietinflammatory markers

Identifiers

PMID33871602
PMCPMC8578836
OpenAlexW3156351647

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.