Evidence map›Paper›PMID 33871501›Full record

ArticleChemical communications (Cambridge, England)2021

Photoactivated release of membrane impermeant sulfonates inside cells.

Stuart T Caldwell, Sean N O'Byrne, Calum Wilson, Filip Cvetko, Michael P Murphy, John G McCarron, Richard C Hartley

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Targeted Fluorogenic Cyanine Carbamates EnableJournal of the American Chemical Society · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Stuart T CaldwellSchool of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK. richard.hartley@glasgow.ac.uk.ORCID http://orcid.org/0000-0003-1604-3462
Sean N O'ByrneSchool of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK. richard.hartley@glasgow.ac.uk.ORCID http://orcid.org/0000-0002-1880-0239
Calum WilsonStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.ORCID http://orcid.org/0000-0003-2500-0632
Filip CvetkoMRC Mitochondrial Biology Unit, Hills Road, University of Cambridge, CB2 0XY, UK.
Michael P MurphyMRC Mitochondrial Biology Unit, Hills Road, University of Cambridge, CB2 0XY, UK.ORCID http://orcid.org/0000-0003-1115-9618
John G McCarronStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.ORCID http://orcid.org/0000-0002-3302-3984
Richard C HartleySchool of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK. richard.hartley@glasgow.ac.uk.ORCID http://orcid.org/0000-0003-1033-5405
University of Glasgow · GBUniversity of Cambridge · GBUniversity of Strathclyde · GB

Funding

Medical Research Council MC_U105663142Wellcome Trust 092292Wellcome Trust 110158Wellcome Trust 110158/Z/15/ZWellcome Trust 110159Wellcome Trust 202924Wellcome Trust 203934Wellcome Trust 204682Wellcome Trust 204682/Z/16/Z
6 · The paper itself

Abstract

Photouncaging delivers compounds with high spatial and temporal control to induce or inhibit biological processes but the released compounds may diffuse out. We here demonstrate that sulfonate anions can be photocaged so that a membrane impermeable compound can enter cells, be uncaged by photoirradiation and trapped within the cell.

Indexed as

AnionsCell Membrane PermeabilityCoumarinsHeLa CellsHumansPhosphatesPhotochemical ProcessesRhodaminesSulfonic AcidsAnionscoumarinCoumarinsPhosphatesRhodaminesSulfonic Acids

Identifiers

PMID33871501
PMCPMC7611313
OpenAlexW3134930944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.