ArticleeLife2021
Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Systems genetic dissection of brain gene expression reveals excitotoxic mechanisms of Alzheimer's disease.Molecular psychiatry · 2026Article
- Genetic analysis of the X-linked adrenoleukodystrophy gene ABCD1 in Drosophila uncovers a conserved phenotype.Communications biology · 2026Article
- circPDE4B downregulation triggers GEMIN5‑dependent translational stress response and autophagy to reduce MAPT pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Network pharmacology approach to unravel the neuroprotective potential of natural products: a narrative review.Molecular diversity · 2026Review
- Two lysosomal genes ATP13A2 and GBA1 interact to drive neurodegeneration.Molecular neurodegeneration · 2026Article
- Revealing the nervous system requirements of Alzheimer disease risk genes in Drosophila.American journal of human genetics · 2025Article
- Multiomics approach identifies SERPINB1 as candidate biomarker for spinocerebellar ataxia type 2.Scientific reports · 2025Article
- Revealing the nervous system requirements of Alzheimer's disease risk genes inbioRxiv : the preprint server for biology · 2025Article
- Multi-epitope immunocapture of huntingtin reveals striatum-selective molecular signatures.Molecular systems biology · 2025Article
- Computational and functional prioritization identifies genes that rescue behavior and reduce tau protein in fly and human cell models of Alzheimer disease.American journal of human genetics · 2025Article
- Haploinsufficiency of ITSN1 is associated with a substantial increased risk of Parkinson's disease.Cell reports · 2025Article
- Longitudinal multi-omics in alpha-synuclein Drosophila model discriminates disease- from age-associated pathologies in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Drosophila glial system: an approach towards understanding molecular complexity of neurodegenerative diseases.Molecular biology reports · 2024Review
- Functional variants identify sex-specific genes and pathways in Alzheimer's Disease.Nature communications · 2023Article
- Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity.PLoS genetics · 2023Article
- An altered extracellular matrix-integrin interface contributes to Huntington's disease-associated CNS dysfunction in glial and vascular cells.Human molecular genetics · 2023Article
- Allele-specific quantitation of ATXN3 and HTT transcripts in polyQ disease models.BMC biology · 2023Article
- Integration of transcriptome-wide association study with neuronal dysfunction assays provides functional genomics evidence for Parkinson's disease genes.Human molecular genetics · 2023Article
- Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits.iScience · 2023Article
- Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders.Nature reviews. Neuroscience · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 3 institutions in 2 countries.
Tarik Seref Onur *Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.ORCID 0000-0002-3234-6263
Andrew Laitman *Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.
He ZhaoJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.
Ryan KeyhoJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.
Hyemin KimJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.
Jennifer WangJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.
Megan MairDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Huilan WangState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Lifang LiDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Alma PerezJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.
Maria de HaroDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Ying-Wooi WanJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.
Genevera AllenJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.
Boxun LuState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Ismael Al-RamahiDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Zhandong LiuJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, United States.
Juan BotasDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.ORCID 0000-0001-5476-5955
Baylor College of Medicine · USNeurological Research Institute · USFudan University · CN
Funding
TRAINING PROGRAM IN COMPUTATIONAL BIOLOGY AND MEDICINET15LM007093 · NLM · RICE UNIVERSITY · PI Lydia E. Kavraki · 1992 to 2026
$20.8MPreclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9MPROGRAM IN HUMAN MOLECULAR GENETICST32GM008307 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI SHAULSKY, GAD · 1990 to 2020
$6.6MFunctional Dissection of Alzheimer's Disease Networks in Drosophila: from Association to Causal Modulators of Age-Dependent NeurodegerationR01AG057339 · NIA · BAYLOR COLLEGE OF MEDICINE · PI BOTAS, JUAN, LIU, ZHANDONG · 2017 to 2021
$3.8MTecan EVO GenePaint robotS10OD016167 · OD · BAYLOR COLLEGE OF MEDICINE · PI LJUNGBERG, CECILIA · 2013 to 2013
$215kNIA NIH HHS R01 AG057339NICHD NIH HHS P50 HD103555NIGMS NIH HHS T32 GM008307NIH HHS S10 OD016167NLM NIH HHS T15 LM007093
Abstract
Most research on neurodegenerative diseases has focused on neurons, yet glia help form and maintain the synapses whose loss is so prominent in these conditions. To investigate the contributions of glia to Huntington's disease (HD), we profiled the gene expression alterations of
Indexed as
Synaptic Transmissionalpha 1-AntitrypsinAnimalsBehavior, AnimalBrainCase-Control StudiesCell Adhesion Molecules, NeuronalCell LineDisease Models, AnimalDrosophila melanogasterDrosophila ProteinsElectrical SynapsesFemaleGene Regulatory NetworksHumansHuntingtin Proteinalpha 1-AntitrypsinCell Adhesion Molecules, NeuronalDrosophila ProteinsHTT protein, humanHtt protein, mouseHuntingtin ProteinNrx protein, Drosophilacomputational biologyD. melanogasterexcitotoxicitygeneticsgenomicsgliahigh-throughput experimentationhumanHuntington's diseasemouseneurodegenerationsynaptic biologysystems biology
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.