Evidence map›Paper›PMID 33870988›Full record

ArticleChemical communications (Cambridge, England)2021

Kathleen E Prosser, Alysia J Kohlbrand, Hyeonglim Seo, Mark Kalaj, Seth M Cohen

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kathleen E ProsserDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. scohen@ucsd.edu.ORCID http://orcid.org/0000-0003-3035-5024
Alysia J KohlbrandDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. scohen@ucsd.edu.ORCID http://orcid.org/0000-0003-4599-526X
Hyeonglim SeoDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. scohen@ucsd.edu.
Mark KalajDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. scohen@ucsd.edu.ORCID http://orcid.org/0000-0001-7139-7517
Seth M CohenDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. scohen@ucsd.edu.ORCID http://orcid.org/0000-0002-5233-2280
University of California System · US

Funding

Metal-binding Isosteres for Influenza Endonuclease Inhibitors and BeyondR01AI149444 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SETH M COHEN · 2020 to 2026
$2.3M
Metallofragments as 3-Dimensional Scaffolds for Fragment-Based Drug DiscoveryR21AI138934 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THEODORAKIS, EMMANUEL A · 2018 to 2019
$402k
NIAID NIH HHS R01 AI149444NIAID NIH HHS R21 AI138934
6 · The paper itself

Abstract

This study demonstrates the screening of a collection of twelve 19F-tagged metal-binding pharmacophores (MBPs) against the Zn(ii)-dependent metalloenzyme human carbonic anhydrase II (hCAII) by 19F NMR. The isomorphous replacement of Zn(ii) by Co(ii) in hCAII produces enhanced sensitivity and reveals the potential of 19F NMR-based techniques for metalloenzyme ligand discovery.

Indexed as

Nuclear Magnetic Resonance, BiomolecularCarbonic Anhydrase IICarbonic Anhydrase InhibitorsCarrier ProteinsCobaltDose-Response Relationship, DrugFluorineHumansLigandsMolecular StructureNerve Tissue ProteinsOrganometallic CompoundsZincCA2 protein, humanCarbonic Anhydrase IICarbonic Anhydrase InhibitorsCarrier ProteinsCobaltFluorineLigandsNerve Tissue ProteinsOrganometallic CompoundsZinc

Identifiers

PMID33870988
PMCPMC8137660
OpenAlexW3143768062

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.