Evidence map›Paper›PMID 33870710›Full record

ArticleJournal of the American Heart Association2021

Risk Factors and Outcomes of Recurrent Drug-Eluting Stent Thrombosis: Insights From the REAL-ST Registry.

Soichiro Enomoto, Shoichi Kuramitsu, Tomohiro Shinozaki, Masanobu Ohya, Hiromasa Otake, Futoshi Yamanaka, Hiroki Shiomi, Masahiro Natsuaki, Gaku Nakazawa, Kenji Ando and 5 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. One-Year Outcomes of Short-Term Dual Antiplatelet Therapy Following Percutaneous Coronary Intervention With Drug-Eluting Stents: A Meta-Analysis of Randomized Clinical Trials.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Prevalence and outcomes of stent thrombosis with in-stent calcified nodules: substudy from the REAL-ST registry.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2022
    Article
  6. Recurrent Stent Thrombosis: An Interventionalist's Nightmare.Journal of the American Heart Association · 2021
    Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 1 country.

Soichiro EnomotoDepartment of Cardiology Tenri Hospital Tenri Japan.
Shoichi KuramitsuDepartment of Cardiology Kokura Memorial Hospital Kitakyushu Japan.
Tomohiro ShinozakiDepartment of Information and Computer Technology Faculty of Engineering Tokyo University of Science Tokyo Japan.
Masanobu OhyaDepartment of Cardiology Kurashiki Central Hospital Kurashiki Japan.
Hiromasa OtakeDivision of Cardiology Department of Internal Medicine Kobe University Graduates School of Medicine Kobe Japan.
Futoshi YamanakaDivision of Cardiology and Catheterization Laboratories Shonan Kamakura General Hospital Kanagawa Japan.
Hiroki ShiomiDepartment of Cardiovascular Medicine Graduate School of Medicine Kyoto University Kyoto Japan.
Masahiro NatsuakiDepartment of Cardiovascular Medicine Saga University Saga Japan.
Gaku NakazawaDivision of Cardiology Department of Medicine Faculty of Medicine Kindai University Osaka Japan.
Kenji AndoDepartment of Cardiology Kokura Memorial Hospital Kitakyushu Japan.
Kazushige KadotaDepartment of Cardiology Kurashiki Central Hospital Kurashiki Japan.
Shigeru SaitoDivision of Cardiology and Catheterization Laboratories Shonan Kamakura General Hospital Kanagawa Japan.
Toshihiro TamuraDepartment of Cardiology Tenri Hospital Tenri Japan.
Takeshi KimuraDepartment of Cardiovascular Medicine Graduate School of Medicine Kyoto University Kyoto Japan.
REAL‐ST investigators †
Kyoto University · JPShonan Kamakura General Hospital · JPTenri Hospital · JPKokura Memorial Hospital · JPKindai University Hospital · JPKobe University · JPKurashiki Central Hospital · JPSaga University · JPTokyo University of Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Stent thrombosis (ST) after drug-eluting stent (DES) implantation remains a life-threatening complication. Recurrent ST (RST) is not a rare phenomenon, potentially contributing to high mortality after the index ST events. However, little evidence is available about the incidence, risk factors, and clinical outcomes of definite RST after DES thrombosis. Methods and Results From REAL-ST (Retrospective Multicenter Registry of ST After First- and Second- Generation DES Implantation), this study evaluated 595 patients with definite ST (first-generation DES thrombosis, n=314; second-generation DES thrombosis, n=281). During a median follow-up of 31 months, we identified 32 patients with definite RST after first-generation DES thrombosis (n=18) and second-generation DES thrombosis (n=15). Cumulative incidence of RST was 4.5% and 6.0% at 1 and 5 years, respectively, which did not significantly differ between first-generation DES thrombosis and second-generation DES thrombosis. Independent predictors of definite RST were early ST (hazard ratio [HR], 2.38; 95% CI, 1.06-5.35 [

Indexed as

RegistriesAgedCoronary AngiographyDrug-Eluting StentsFemaleFollow-Up StudiesGraft Occlusion, VascularHumansIncidenceJapanMaleMiddle AgedPercutaneous Coronary InterventionRecurrenceRetrospective StudiesRisk Assessmentdrug‐eluting stentpercutaneous coronary interventionrecurrent stent thrombosis

Identifiers

PMID33870710
PMCPMC8200759
OpenAlexW3153737303

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.