Evidence map›Paper›PMID 33870128›Full record

ArticleiScience2021

BCL11B is positioned upstream of PLZF and RORγt to control thymic development of mucosal-associated invariant T cells and MAIT17 program.

Theodore T Drashansky, Eric Y Helm, Nina Curkovic, Jaimee Cooper, Pingyan Cheng, Xianghong Chen, Namrata Gautam, Lingsong Meng, Alexander J Kwiatkowski, William O Collins and 6 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Development of αβ and γδ T Cells in the Thymus and Methods of Analysis.International journal of molecular sciences · 2025
    Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Theodore T DrashanskyDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Eric Y HelmDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Nina CurkovicDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Jaimee CooperDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Pingyan ChengDepartment of Immunology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr, Tampa, FL 33612, USA.
Xianghong ChenDepartment of Immunology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr, Tampa, FL 33612, USA.
Namrata GautamDepartment of Immunology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr, Tampa, FL 33612, USA.
Lingsong MengDepartment of Biostatistics, College of Medicine, College of Public Health & Health Professions, University of Florida, Gainesville, FL 32611, USA.
Alexander J KwiatkowskiJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
William O CollinsDepartment of Otolaryngology, College of Medicine, University of Florida, Gainesville, FL 32605, USA.
Benjamin G KeselowskyJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
Derek Sant'AngeloDepartment of Pediatrics, The Child Health Institute of NJ, Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA.
Zhiguang HuoDepartment of Biostatistics, College of Medicine, College of Public Health & Health Professions, University of Florida, Gainesville, FL 32611, USA.
Weizhou ZhangDepartment of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Liang ZhouUF Health Cancer Center, Gainesville, FL 32610, USA.
Dorina AvramDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
University of Florida · USMoffitt Cancer Center · USUniversity of Florida Health · US

Funding

Role of Bcl11b in CD4+ T cells and innate lymphoid cellsR01AI067846 · NIAID · UNIVERSITY OF FLORIDA · PI AVRAM, DORINA · 2007 to 2023
$6.2M
Obesity, inflammation and breast cancerR01CA200673 · NCI · UNIVERSITY OF IOWA · PI ZHANG, WEIZHOU · 2016 to 2020
$1.7M
6 · The paper itself

Abstract

Mucosal-associated invariant T (MAIT) cells recognize microbial riboflavin metabolites presented by MR1 and play role in immune responses to microbial infections and tumors. We report here that absence of the transcription factor (TF) Bcl11b in mice alters predominantly MAIT17 cells in the thymus and further in the lung, both at steady state and following

Indexed as

ImmunologySystems BiologyTranscriptomics

Identifiers

PMID33870128
PMCPMC8042176
OpenAlexW3137852925

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.