Evidence map›Paper›PMID 33870104›Full record

ArticleAdvanced photonics2020

High spatial and temporal resolution synthetic aperture phase microscopy.

Cheng Zheng, Di Jin, Yanping He, Hongtao Lin, Juejun Hu, Zahid Yaqoob, Peter T C So, Renjie Zhou

Abstract read
In one paragraph

Article in Advanced photonics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Multiscale aperture synthesis imager.Nature communications · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cheng ZhengThe Chinese University of Hong Kong, Department of Biomedical Engineering, Hong Kong, China.
Di JinMassachusetts Institute of Technology, Computer Science and Artificial Intelligence Laboratory, Cambridge, Massachusetts, United States.
Yanping HeThe Chinese University of Hong Kong, Department of Biomedical Engineering, Hong Kong, China.
Hongtao LinZhejiang University, College of Information Science and Electronic Engineering, Hangzhou, China.
Juejun HuMassachusetts Institute of Technology, Department of Materials Science and Engineering, Cambridge, Massachusetts, United States.
Zahid YaqoobMassachusetts Institute of Technology, Laser Biomedical Research Center, Cambridge, Massachusetts, United States.
Peter T C SoMassachusetts Institute of Technology, Department of Mechanical Engineering, Cambridge, Massachusetts, United States.
Renjie ZhouThe Chinese University of Hong Kong, Department of Biomedical Engineering, Hong Kong, China.ORCID 0000-0002-4761-6641

Funding

Wide-Field Short-Wave Infrared (SWIR) multiphoton (MP) tissue imagingP41EB015871 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SO, PETER T. · 2012 to 2021
$11.3M
NIBIB NIH HHS P41 EB015871
6 · The paper itself

Abstract

A new optical microscopy technique, termed high spatial and temporal resolution synthetic aperture phase microscopy (HISTR-SAPM), is proposed to improve the lateral resolution of wide-field coherent imaging. Under plane wave illumination, the resolution is increased by twofold to around 260 nm, while achieving millisecond-level temporal resolution. In HISTR-SAPM, digital micromirror devices are used to actively change the sample illumination beam angle at high speed with high stability. An off-axis interferometer is used to measure the sample scattered complex fields, which are then processed to reconstruct high-resolution phase images. Using HISTR-SAPM, we are able to map the height profiles of subwavelength photonic structures and resolve the period structures that have 198 nm linewidth and 132 nm gap (i.e., a full pitch of 330 nm). As the reconstruction averages out laser speckle noise while maintaining high temporal resolution, HISTR-SAPM further enables imaging and quantification of nanoscale dynamics of live cells, such as red blood cell membrane fluctuations and subcellular structure dynamics within nucleated cells. We envision that HISTR-SAPM will broadly benefit research in material science and biology.

Indexed as

cell dynamics observationlabel-free imagingmaterial inspectionquantitative phase microscopy

Identifiers

PMID33870104
PMCPMC8049284

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.