ArticleResearch and practice in thrombosis and haemostasis2021
Anticoagulated patients exhibit intact endogenous thrombin potential using ST Genesia unlike the Calibrated Automated Thrombogram.
Article in Research and practice in thrombosis and haemostasis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
- Fibrinography and thrombography (thrombodynamics-4D) in atrial fibrillation assessment of direct oral anticoagulants in geriatrics patients aged 80 years and older receiving direct oral anticoagulant therapy.Research and practice in thrombosis and haemostasis · 2025Article
- Comparison is not reason: Pitfalls in reporting thrombin generation results in anticoagulated patients.Research and practice in thrombosis and haemostasis · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe thrombin generation (TG) assay is a feasible but labor-intensive method for detecting global coagulation. It enables comprehensive assessment of anticoagulation, while drug-specific assays assess only exposure. Traditionally, the Calibrated Automated Thrombogram (CAT) has been used, however the ST Genesia (Diagnostica Stago) allows automated evaluation.
objectiveWe aimed to observe coagulation using the ST Genesia and compare the data with those of CAT in anticoagulated patients. PATIENTS AND
methodsIn total, 43 frozen-thawed samples were studied using DrugScreen to assess direct oral anticoagulants (DOACs), warfarin, and low-molecular-weight heparin. Twenty samples (nine rivaroxaban, five apixaban, three warfarin, and three heparin) were also compared using CAT (5 pM tissue factor).
resultsTG reduction in DrugScreen depended on the specific drug and modestly correlated with DOAC levels (lag time R
conclusionThe ST Genesia data did not correlate with CAT, but it was independently associated with INR, anti-Xa, and DOAC concentrations. The lag time and peak responses were similar; the major differences were that ST Genesia showed no ETP effect of DOACs and failed to give readout at high INR or anti-Xa activity.
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