ArticleEnvironmental epidemiology (Philadelphia, Pa.)2021
Prenatal metal mixtures and sex-specific infant negative affectivity.
Article in Environmental epidemiology (Philadelphia, Pa.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Heavy Metal Exposure During Pregnancy and Its Association With Adverse Birth Outcomes: A Cross-Sectional Study.GeoHealth · 2025Article
- Prenatal exposure to manganese and objectively measured sleep disturbances in early childhood.Environmental research · 2025Article
- Review
- Infant cognitive home environment as a moderator for the association of prenatal lead on child language.Neurotoxicology · 2025Article
- Associations of prenatal metal exposure with child neurodevelopment and mediation by perturbation of metabolic pathways.Nature communications · 2025Article
- Individual and joint effects of prenatal PMEnvironmental research · 2024Article
- Cross-sectional and prospective associations of early childhood circulating metals with early and mid-childhood cognition in the Project Viva cohort.Environmental research · 2024Article
- An Industry-Relevant Metal Mixture, Iron Status, and Reported Attention-Related Behaviors in Italian Adolescents.Environmental health perspectives · 2024Article
- Mixtures of Metals and Micronutrients in Early Pregnancy and Cognition in Early and Mid-Childhood: Findings from the Project Viva Cohort.Environmental health perspectives · 2023Article
- Environmental chemical exposures and mental health outcomes in children: a narrative review of recent literature.Frontiers in toxicology · 2023Review
- Prenatal exposure to heavy metal mixtures and anthropometric birth outcomes: a cross-sectional study.Environmental health : a global access science source · 2022Article
- Individual Nutrition Is Associated with Altered Gut Microbiome Composition for Adults with Food Insecurity.Nutrients · 2022Article
- Joint associations among prenatal metal mixtures and nutritional factors on birth weight z-score: Evidence from an urban U.S. population.Environmental research · 2022Article
- Prenatal exposure to a mixture of organochlorines and metals and internalizing symptoms in childhood and adolescence.Environmental research · 2022Article
- Prenatal trace elements mixture is associated with learning deficits on a behavioral acquisition task among young children.New directions for child and adolescent development · 2022Article
- Using Metrics of a Mixture Effect and Nutrition from an Observational Study for Consideration towards Causal Inference.International journal of environmental research and public health · 2022Observational
- Associations between a metal mixture and infant negative affectivity: Effect modification by prenatal cortisol and infant sex.Child developmentArticle
- Maternal prenatal lead levels and neonatal brain volumes: Testing moderations by maternal depressive symptoms and family income.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Prenatal exposure to metals has been associated with a range of adverse neurocognitive outcomes; however, associations with early behavioral development are less well understood. We examined joint exposure to multiple co-occurring metals in relation to infant negative affect, a stable temperamental trait linked to psychopathology among children and adults.
methodsAnalyses included 308 mother-infant pairs enrolled in the PRISM pregnancy cohort. We measured As, Ba, Cd, Cs, Cr, Pb, and Sb in urine, collected on average during late pregnancy, by ICP-MS. At age 6 months, we assessed negative affect using the Infant Behavior Questionnaire-Revised. We used Weighted Quantile Sum (WQS) regression with repeated holdout validation to estimate the joint association between the metals and global negative affectivity, as well as four subdomains (Fear, Sadness, Distress to Limitations, and Falling Reactivity). We also tested for a sex interaction with estimated stratified weights.
resultsIn adjusted models, urinary metals were associated with higher scores on the Fear scale (β
conclusionsPrenatal exposure to metals was associated with increased infant scores on the temperamental domain of fear, with girls showing particular sensitivity.Key words: Prenatal; Metals; Mixtures; Temperament; Infancy; Negative affect.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.