ArticleEnvironmental epidemiology (Philadelphia, Pa.)2021
The mediation effect of placental weight change in the association between prenatal exposure to selenium and birth weight: Evidence from a prospective birth cohort study in China.
Article in Environmental epidemiology (Philadelphia, Pa.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 12 citations in OpenAlex.
- Associations between maternal and infant selenium status and child growth in a birth cohort from Dhaka, Bangladesh.The British journal of nutrition · 2023Trial
- Article
- Prenatal exposure to metal mixture and birth weight; a Bayesian kernel machine regression analysis of two cohort studies in Japan and Iran.Journal of environmental health science & engineering · 2025Article
- Combining Transcriptomics and Proteomics to Screen Candidate Genes Related to Bovine Birth Weight.Animals : an open access journal from MDPI · 2024Article
- Urinary heavy metals in residents from a typical city in South China: human exposure and health risks.Environmental science and pollution research international · 2022Article
- The Seroprevalence of Dengue Virus Infection and Its Association With Iron (Fe) Level in Pregnant Women in Guangzhou, China.Frontiers in medicine · 2021Article
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23 authors at 5 institutions in 1 country.
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Abstract
Selenium (Se) is an essential element and also toxic at an excessive level for human body. However, few studies have investigated adverse effects of Se exposure on birth weight and placental weight.
methodsAll participants were selected from the Prenatal Environment and Offspring Health cohort conducted in 2016 in Guangzhou, China. Se in each participant was measured by inductively coupled plasma mass spectrometry in their urine samples. The urinary Se concentrations were corrected by creatinine and transformed by natural logarithm (ln-Se). Multiple-linear regression models were applied to estimate the associations among Se exposure levels, placenta weight, and birth weight.
resultsA total of 2758 mother-newborn pairs were included in this study. Each interquartile range (0.53 μg/g creatinine) increment in urine ln-Se concentration during the first trimester was associated with a mean 21.7 g (95% CI = -41.3g to -2.1g) decrease in birth weight and 3.6g (95% CI = -6.3g to -0.9g) decrease in placental weight. Compared with the lowest quartile (Q1) of ln-Se concentrations during the first trimester, significantly lower birth weight was found in the highest quartile (Q4) (β = -45.7g; 95% CI = -90.7g to -0.7g). Similar dose-response associations with birthweight and placental weight were found for Se exposure during the third trimester. Mediation analyses showed that 44.2% and 18.2% of the effects of Se exposure in first and third trimester on birth weight were mediated by decreased placental weight, respectively.
conclusionMaternal Se exposure during pregnancy was negatively associated with birth weight, the reduction of placental weight may partially mediate the association of prenatal Se exposure with birth weight.
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