Evidence map›Paper›PMID 33869898›Full record

ArticleBioactive materials2021

Intelligent nanogels with self-adaptive responsiveness for improved tumor drug delivery and augmented chemotherapy.

Xin Li, Helin Li, Changchang Zhang, Andrij Pich, Lingxi Xing, Xiangyang Shi

Abstract read
In one paragraph

Article in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Polymeric Nanogels for Antimicrobial Therapy.Gels (Basel, Switzerland) · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Detection and Inhibition ofPathogens (Basel, Switzerland) · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Hydrogel co-loading SOFrontiers in bioengineering and biotechnology · 2022
    Article
  18. Article
  19. Review
  20. Emerging 2D Nanomaterials for Multimodel Theranostics of Cancer.Frontiers in bioengineering and biotechnology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xin LiDepartment of Gynecology and Obstetrics, XinHua Hospital Affiliated to Shanghai JiaoTong University School of Medicine, Shanghai, 200092, China.
Helin LiDWI-Leibniz-Institute for Interactive Materials e.V., 52056, Aachen, Germany.
Changchang ZhangCollege of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China.
Andrij PichDWI-Leibniz-Institute for Interactive Materials e.V., 52056, Aachen, Germany.
Lingxi XingDepartment of Gynecology and Obstetrics, XinHua Hospital Affiliated to Shanghai JiaoTong University School of Medicine, Shanghai, 200092, China.
Xiangyang ShiCollege of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For cancer nanomedicine, the main goal is to deliver therapeutic agents effectively to solid tumors. Here, we report the unique design of self-adaptive ultrafast charge-reversible chitosan-polypyrrole nanogels (CH-PPy NGs) for enhanced tumor delivery and augmented chemotherapy. CH was first grafted with PPy to form CH-PPy polymers that were used to form CH-PPy NGs through glutaraldehyde cross-linking

Indexed as

Active transportationDeep tumor penetrationEnhanced antitumor activityNanogelsUltrafast charge conversion

Identifiers

PMID33869898
PMCPMC8024537

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.