ReviewNeurobiology of stress2021
Glucocorticoids, the evolution of the stress-response, and the primate predicament.
Review in Neurobiology of stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- Chronic psychosocial stress: a role in breast cancer etiology?Frontiers in oncology · 2026Pooled it
- Interpersonal early adversity demonstrates dissimilarity from early socioeconomic disadvantage in the course of human brain development: A meta-analysis.Neuroscience and biobehavioral reviews · 2023Pooled it
- When Does Stress Build Strength? Linking Stress Physiology to Resilience in the Age of Rapid Environmental Change.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Corticosterone Concentration Varies With Metabolic Rate in Vertebrates.Ecology and evolution · 2026Article
- Using insertable cardiac monitors to test determinants of heart rate and activity in captive baboons.Animal biotelemetry · 2026Article
- On the Limitations of Burnout as an Indicator of Job-Related Distress.Annals of the New York Academy of Sciences · 2026Review
- Recalled Adverse Childhood Experiences Predict Behavioral Traits Associated With an Accelerated Life History in Cebu, Philippines.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- Chronic High-Carbohydrate And High-Fat Diet-Induced Metabolic Syndrome Leads To Adrenal Dysfunction, Altered Dendritic Morphology In Limbic Regions, And Anxiety-Like Behaviors In Male Rats.Journal of molecular neuroscience : MN · 2026Article
- Neuroendocrine-associated epigenetic factors in cellular senescence: mechanisms and therapeutic implications.Biogerontology · 2026Review
- Not All Stress Is the Same: Variable Associations Between Psychosocial Stressors and Urinary Cortisol Rhythms in a Small-Scale Subsistence Society.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- Exploring behavioral outcomes of gonadectomy in pets: a need for personalized approaches.Animal reproduction · 2026Review
- Positive Cortisol-Testosterone Hormonal Coupling Among Adolescents in Argentina and Jordan.American journal of biological anthropology · 2025Article
- Effects of Variations in Daily Cortisol Pattern and Long-Term Cortisol Output on Hippocampal Subfield Volumes in the Adult Human Brain.Biological psychiatry global open science · 2025Article
- Circulating Epstein-Barr Virus Antibody Levels as a Biomarker of Socioecological Adversity in Amazonian Ecuador.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Stress responsiveness in a wild primate predicts survival across an extreme El Niño drought.Science advances · 2025Article
- Psychopathology as long-term sequelae of maltreatment and socioeconomic disadvantage: Neurocognitive development perspectives.Development and psychopathology · 2024Article
- Effects of chronic stress on cognitive function - From neurobiology to intervention.Neurobiology of stress · 2024Review
- More allogrooming is followed by higher physiological stress in wild female baboons.Biology letters · 2024Article
- ROS formation, mitochondrial potential and osmotic stability of the lamprey red blood cells: effect of adrenergic stimulation and hypoosmotic stress.Fish physiology and biochemistry · 2024Article
- Stress Responses Among Individuals with Spiritual Struggles in Hungary: An Experimental Study.Journal of religion and health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adrenocortical stress-response is extraordinarily conserved across mammals, birds, fish, reptiles, and amphibians, suggesting that it has been present during the hundreds of millions of years of vertebrate existence. Given that antiquity, it is relatively recent that primate social complexity has evolved to the point that, uniquely, life can be dominated by chronic psychosocial stress. This paper first reviews adrenocortical evolution during vertebrate history. This produces a consistent theme of there being an evolutionary tradeoff between the protective effects of glucocorticoids during an ongoing physical stressor, versus the adverse long-term consequences of excessive glucocorticoid secretion; how this tradeoff is resolved depends on particular life history strategies of populations, species and vertebrate taxa. This contrasts with adrenocortical evolution in socially complex primates, who mal-adaptively activate the classic vertebrate stress-response during chronic psychosocial stress. This emphasizes the rather unique and ongoing selective forces sculpting the stress-response in primates, including humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.