ArticleCurrent opinion in behavioral sciences2021
Is the core function of orbitofrontal cortex to signal values or make predictions?
Article in Current opinion in behavioral sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- Chemogenetic inhibition of the ventrolateral orbitofrontal cortex disrupts novelty-guided updating of spatial memories and alters hippocampal engram reactivation.Psychopharmacology · 2026Article
- Neuromodulators of orbitofrontal cortex function: A review of endocannabinoid, neurotrophin, and cell adhesion systems.Neurobiology of disease · 2026Review
- Orbitofrontal Cortex Encodes Decision Signals during Value-based But Not Perceptual Decisions.Journal of cognitive neuroscience · 2026Article
- Control of associative learning by the mediodorsal thalamus-orbitofrontal cortex circuit.Nature communications · 2026Article
- A comprehensive multimodal MRI and EEG-TMS dataset on the impact of parietal cortex inhibition on decision-making under ambiguity.Data in brief · 2026Article
- Complementary yet Dissociable Influences of Medial and Lateral Orbitofrontal Cortex over Cue-Guided Decisions Involving Reward Magnitude and Uncertainty.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Compare first, evaluate later: Upending the neuroscience of choice.PLoS biology · 2025Article
- Shared orbitofrontal dynamics to a drug-themed movie track craving and recovery in heroin addiction.Brain : a journal of neurology · 2025Article
- Schemas, reinforcement learning and the medial prefrontal cortex.Nature reviews. Neuroscience · 2025Review
- Applications of Behavioral Economics and Neuroeconomics in Mental Health.Iranian journal of psychiatry · 2025Review
- Brain signatures of catastrophic events: Emotion, salience, and cognitive control.Psychophysiology · 2024Article
- Cracking and Packing Information about the Features of Expected Rewards in the Orbitofrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Appetitive conditioning with pornographic stimuli elicits stronger activation in reward regions than monetary and gaming-related stimuli.Human brain mapping · 2024Article
- Naturalistic drug cue reactivity in heroin use disorder: orbitofrontal synchronization as a marker of craving and recovery.medRxiv : the preprint server for health sciences · 2024Article
- Noradrenergic regulation of cue-guided decision making and impulsivity is doubly dissociable across frontal brain regions.Psychopharmacology · 2024Article
- Article
- Laser stimulation of the skin for quantitative study of decision-making and motivation.Cell reports methods · 2022Article
- The orbitofrontal cortex represents advantageous choice in the Iowa gambling task.Human brain mapping · 2022Article
- Orbitofrontal cortex governs working memory for temporal order.Current biology : CB · 2022Article
- The whole prefrontal cortex is premotor cortex.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
One dominant hypothesis about the function of the orbitofrontal cortex (OFC) is that the OFC signals the subjective values of possible outcomes to other brain areas for learning and decision making. This popular view generally neglects the fact that OFC is not necessary for simple value-based behavior (i.e., when values have been directly experienced). An alternative, emerging view suggests that OFC plays a more general role in representing structural information about the task or environment, derived from prior experience, and relevant to predicting behavioral outcomes, such as value. From this perspective, value signaling is simply one derivative of the core underlying function of OFC. New data in favor of both views have been accumulating rapidly. Here we review these new data in discussing the relative merits of these two ideas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.