Evidence map›Paper›PMID 33869660›Full record

ArticleCellR4-- repair, replacement, regeneration, & reprogramming2014

Exosomes in the Pathogenesis, Diagnosis and Treatment of Pancreatic Diseases.

M Garcia-Contreras, C Ricordi, P D Robbins, E Oltra

Abstract read
In one paragraph

Article in CellR4-- repair, replacement, regeneration, & reprogramming, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

M Garcia-ContrerasFacultad de Medicina, Universidad Católica de Valencia "San Vicente Mártir", Valencia, Spain.
C RicordiDiabetes Research Institute (DRI) and Cell Transplant Program, University of Miami Miller School of Medicine, Miami, FL, USA.
P D RobbinsDepartment of Metabolism and Aging Scripps Florida, Jupiter, FL, USA.
E OltraFacultad de Medicina, Universidad Católica de Valencia "San Vicente Mártir", Valencia, Spain.

Funding

Strategies to Improve Long Term Islet Graft SurvivalU01DK070460 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RICORDI, CAMILLO · 2004 to 2012
$11.6M
NIDDK NIH HHS U01 DK070460
6 · The paper itself

Abstract

Exosomes (EXOs) are small vesicles (30-200 nm) of endocytic origin, which are released by many different cell types into the extracellular space. They may play a key role in facilitating cell-cell communication, under both physiological and pathological conditions. EXOs contain a wide range of RNA molecules and proteins. Their specific molecular signatures make them promising candidates in early diagnosis and prognosis of pancreatic diseases. EXOs could also provide a new method to monitor treatment response in patients suffering from pancreatic cancer and other diseases of the pancreas. Additionally they may help to improve current treatments via personalized medicine approaches using them as therapeutic vehicles themselves.

Identifiers

PMID33869660
PMCPMC8048207

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.