Evidence map›Paper›PMID 33869642›Full record

ArticleOrthopaedic journal of sports medicine2021

Hyperlipidemia Is a Risk Factor of Adhesive Capsulitis: Real-World Evidence Using the Taiwanese National Health Insurance Research Database.

Jr-Yi Wang, Chen-Kun Liaw, Chi-Chang Huang, Tsan-Hon Liou, Hui-Wen Lin, Shih-Wei Huang

Open access · goldAbstract read
In one paragraph

Article in Orthopaedic journal of sports medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  8. Article
  9. Rat models of frozen shoulder: Classification and evaluation.Animal models and experimental medicine · 2025
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  13. Observational
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  18. Frozen shoulder.Nature reviews. Disease primers · 2022
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jr-Yi WangDepartment of Orthopedic Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City.
Chen-Kun LiawDepartment of Orthopedic Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City.
Chi-Chang HuangGraduate Institute of Sports Science, National Taiwan Sport University, Taoyuan.
Tsan-Hon LiouDepartment of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei.
Hui-Wen LinDepartment of Mathematics, Soochow University, Taipei.
Shih-Wei HuangGraduate Institute of Sports Science, National Taiwan Sport University, Taoyuan.
Taipei Medical University · TWNational Taiwan Sport University · TWSoochow University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with adhesive capsulitis are evaluated for pain and progressive contracture of the glenohumeral joint. Whether endocrine, immune, or inflammatory processes are involved in its definite pathogenesis is still under debate. Some cross-sectional studies with a small sample size have noted that hyperlipidemia is a possible risk factor for frozen shoulders. PURPOSE/HYPOTHESIS: The purpose was to conduct a longitudinal population-based study to investigate the risk of adhesive capsulitis among patients with hyperlipidemia. It was hypothesized that patients with hyperlipidemia would have a higher risk of adhesive capsulitis and that the use of statin drugs could reduce the rate. STUDY

designCohort study; Level of evidence, 3.

methodsUsing data from the National Health Insurance Research Database (NHIRD) of Taiwan, the authors obtained the records of patients with hyperlipidemia who received a diagnosis between 2004 and 2005 and were followed up until the end of 2010. The control cohort comprised age- and sex-matched patients without hyperlipidemia. Propensity score matching was performed for the other comorbidities. A Cox multivariate proportional hazards model was applied to analyze the risk factors of adhesive capsulitis. The hazard ratio (HR) and adjusted HR were estimated between the study and control cohorts after adjustment for confounders. The effects of statin use on adhesive capsulitis risk were also analyzed.

resultsThe NHIRD records of 28,748 patients and 114,992 propensity score-matched controls were evaluated. A higher incidence rate of adhesive capsulitis was revealed in the hyperlipidemia cohort, with a crude HR of 1.70 (95% CI, 1.61-1.79;

conclusionPatients with hyperlipidemia had a 1.5-fold higher risk of adhesive capsulitis than did healthy controls. Statin use did not provide protection against adhesive capsulitis in patients with hyperlipidemia.

Indexed as

adhesive capsulitisfrozen shoulderhyperlipidemiapopulation-based study

Identifiers

PMID33869642
PMCPMC8024456
OpenAlexW3147219349

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.