Evidence map›Paper›PMID 33869277›Full record

ArticleFrontiers in molecular biosciences2021

miR-7b-3p Exerts a Dual Role After Spinal Cord Injury, by Supporting Plasticity and Neuroprotection at Cortical Level.

Matilde Ghibaudi, Marina Boido, Darrell Green, Elena Signorino, Gaia Elena Berto, Soraya Pourshayesteh, Archana Singh, Ferdinando Di Cunto, Tamas Dalmay, Alessandro Vercelli

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  3. NcRNAs: a potential treatment for spinal cord injury.Frontiers in cellular neuroscience · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Matilde GhibaudiDepartment of Neuroscience "Rita Levi Montalcini," Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Orbassano, Italy.
Marina BoidoDepartment of Neuroscience "Rita Levi Montalcini," Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Orbassano, Italy.
Darrell GreenNorwich Medical School, University of East Anglia, Norwich, United Kingdom.
Elena SignorinoDepartment of Neuroscience "Rita Levi Montalcini," Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Orbassano, Italy.
Gaia Elena BertoDepartment of Neuroscience "Rita Levi Montalcini," Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Orbassano, Italy.
Soraya PourshayestehDepartment of Neuroscience "Rita Levi Montalcini," Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Orbassano, Italy.
Archana SinghSchool of Biological Sciences, University of East Anglia, Norwich, United Kingdom.
Ferdinando Di CuntoDepartment of Neuroscience "Rita Levi Montalcini," Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Orbassano, Italy.
Tamas DalmaySchool of Biological Sciences, University of East Anglia, Norwich, United Kingdom.
Alessandro VercelliDepartment of Neuroscience "Rita Levi Montalcini," Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Orbassano, Italy.
University of Turin · ITNeuroscience Institute · ITUniversity of East Anglia · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) affects 6 million people worldwide with no available treatment. Despite research advances, the inherent poor regeneration potential of the central nervous system remains a major hurdle. Small RNAs (sRNAs) 19-33 nucleotides in length are a set of non-coding RNA molecules that regulate gene expression and have emerged as key players in regulating cellular events occurring after SCI. Here we profiled a class of sRNA known as microRNAs (miRNAs) following SCI in the cortex where the cell bodies of corticospinal motor neurons are located. We identified miR-7b-3p as a candidate target given its significant upregulation after SCI

Indexed as

axon regenerationmiRNAsneuronal developmentspinal cord injurysproutingWipf2

Identifiers

PMID33869277
PMCPMC8044879
OpenAlexW3150154798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.