Evidence map›Paper›PMID 33869205›Full record

ArticleFrontiers in cell and developmental biology2021

Inhibiting miR-22 Alleviates Cardiac Dysfunction by Regulating Sirt1 in Septic Cardiomyopathy.

Runze Wang, Yuerong Xu, Wei Zhang, Yexian Fang, Tiqun Yang, Di Zeng, Ting Wei, Jing Liu, Haijia Zhou, Yan Li and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. The Role of microRNA-22 in Metabolism.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Regulated cell death pathways in cardiomyopathy.Acta pharmacologica Sinica · 2023
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Runze WangDepartment of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Yuerong XuDepartment of Orthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, China.
Wei ZhangDepartment of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Yexian FangDepartment of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Tiqun YangDepartment of Cardiology, Center for Translational Medicine, The First Affiliated Hospital, Institute of Precision Medicine, Sun Yat-sen University, Guangzhou, China.
Di ZengDepartment of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Ting WeiDepartment of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Jing LiuDepartment of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Haijia ZhouDepartment of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Yan LiDepartment of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Zhan-Peng HuangDepartment of Cardiology, Center for Translational Medicine, The First Affiliated Hospital, Institute of Precision Medicine, Sun Yat-sen University, Guangzhou, China.
Mingming ZhangDepartment of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Air Force Medical University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High morbidity and mortality are the most typical characteristics of septic cardiomyopathy. We aimed to reveal the role of miR-22 in septic cardiomyopathy and to explore the underlying mechanisms. miR-22 cardiac-specific knockout (miR-22

Indexed as

apoptosisautophagymiR-22septic cardiomyopathysirt1

Identifiers

PMID33869205
PMCPMC8047209
OpenAlexW3214403556

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.