Evidence map›Paper›PMID 33869199›Full record

ReviewFrontiers in cell and developmental biology2021

Advances in the Role of Leucine-Sensing in the Regulation of Protein Synthesis in Aging Skeletal Muscle.

Yan Zhao, Jason Cholewa, Huayu Shang, Yueqin Yang, Xiaomin Ding, Qianjin Wang, Quansheng Su, Nelo Eidy Zanchi, Zhi Xia

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Defatted chia (Current research in food science · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Nutrient sensors and their crosstalk.Experimental & molecular medicine · 2023
    Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Yan ZhaoExercise Physiology and Biochemistry Laboratory, College of Physical Education, Jinggangshan University, Ji'an, China.
Jason CholewaDepartment of Exercise Physiology, University of Lynchburg, Lynchburg, VA, United States.
Huayu ShangSchool of Sport Medicine and Health, Chengdu Sport University, Chengdu, China.
Yueqin YangHubei Provincial Collaborative Innovation Center for Exercise and Health Promotion, College of Health Science, Wuhan Sports University, Wuhan, China.
Xiaomin DingExercise Physiology and Biochemistry Laboratory, College of Physical Education, Jinggangshan University, Ji'an, China.
Qianjin WangExercise Physiology and Biochemistry Laboratory, College of Physical Education, Jinggangshan University, Ji'an, China.
Quansheng SuSchool of Sport Medicine and Health, Chengdu Sport University, Chengdu, China.
Nelo Eidy ZanchiDepartment of Physical Education, Federal University of Maranhão (UFMA), São Luís-MA, Brazil.
Zhi XiaExercise Physiology and Biochemistry Laboratory, College of Physical Education, Jinggangshan University, Ji'an, China.
Chengdu Sport University · CNJinggangshan University · CNUniversidade Federal do Maranhão · BRUniversity of Lynchburg · USWuhan Sports University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal muscle anabolic resistance (i.e., the decrease in muscle protein synthesis (MPS) in response to anabolic stimuli such as amino acids and exercise) has been identified as a major cause of age-related sarcopenia, to which blunted nutrition-sensing contributes. In recent years, it has been suggested that a leucine sensor may function as a rate-limiting factor in skeletal MPS via small-molecule GTPase. Leucine-sensing and response may therefore have important therapeutic potential in the steady regulation of protein metabolism in aging skeletal muscle. This paper systematically summarizes the three critical processes involved in the leucine-sensing and response process: (1) How the coincidence detector mammalian target of rapamycin complex 1 localizes on the surface of lysosome and how its crucial upstream regulators Rheb and RagB/RagD interact to modulate the leucine response; (2) how complexes such as Ragulator, GATOR, FLCN, and TSC control the nucleotide loading state of Rheb and RagB/RagD to modulate their functional activity; and (3) how the identified leucine sensor leucyl-tRNA synthetase (LARS) and stress response protein 2 (Sestrin2) participate in the leucine-sensing process and the activation of RagB/RagD. Finally, we discuss the potential mechanistic role of exercise and its interactions with leucine-sensing and anabolic responses.

Indexed as

age-related sarcopeniaanabolic resistanceleucine responseleucine-sensingprotein synthesis

Identifiers

PMID33869199
PMCPMC8047301
OpenAlexW3140155338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.